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Kinetic Resolution of 2-Substituted 2,3-Dihydro-4-pyridones by Palladium-Catalyzed Asymmetric Allylic Alkylation: Catalytic Asymmetric Total Synthesis of Indolizidine (-)-209I
Alternative Title钯催化烯丙基取代反应对2-取代-2,3-二氢哌啶酮的动力学拆分: Indizidine (-)-209I 的催化不对称全合成
Lei BL(雷柏林); Zhang QS(张卿菘); Yu WH(余伟华); Ding QP(丁秋平); Ding CH(丁昌华); Hou XL(侯雪龙)
2014
Source PublicationOrg. Lett.
Volume16Issue:7Pages:1944-1947
AbstractThe kinetic resolution of 2-substituted-2,3-dihydro-4-pyridones was realized via a Pd-catalyzed allylic substitution reaction using a commercially available (S)-P-Phos as a ligand, affording optically active dihydropyridones and C-allylated dihydropyridones in high yields and good enantioselectivities with the S-factor up to 43. With this protocol, a catalytic asymmetric total synthesis of indolizidine (-)-209I was realized for the first time.
Subject Area金属有机化学
DOI10.1021/ol500498m
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Indexed BySCI
Language英语
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Cited Times:15[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.sioc.ac.cn/handle/331003/39050
Collection金属有机化学国家重点实验室
Corresponding AuthorDing CH(丁昌华); Hou XL(侯雪龙)
Affiliation中科院上海有机化学研究所
Recommended Citation
GB/T 7714
Lei BL,Zhang QS,Yu WH,et al. Kinetic Resolution of 2-Substituted 2,3-Dihydro-4-pyridones by Palladium-Catalyzed Asymmetric Allylic Alkylation: Catalytic Asymmetric Total Synthesis of Indolizidine (-)-209I[J]. Org. Lett.,2014,16(7):1944-1947.
APA 雷柏林,张卿菘,余伟华,丁秋平,丁昌华,&侯雪龙.(2014).Kinetic Resolution of 2-Substituted 2,3-Dihydro-4-pyridones by Palladium-Catalyzed Asymmetric Allylic Alkylation: Catalytic Asymmetric Total Synthesis of Indolizidine (-)-209I.Org. Lett.,16(7),1944-1947.
MLA 雷柏林,et al."Kinetic Resolution of 2-Substituted 2,3-Dihydro-4-pyridones by Palladium-Catalyzed Asymmetric Allylic Alkylation: Catalytic Asymmetric Total Synthesis of Indolizidine (-)-209I".Org. Lett. 16.7(2014):1944-1947.
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