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Titanium-mediated reductive cross-coupling reactions of imines with nitriles: an efficient route for the synthesis of alpha-aminoketones or 1,2-diketones
Alternative Title钛促进的亚胺与氰基亚胺的还原交叉偶联反应: a-氨基酮与1,2-二羰基衍生物的合成
Chen HY(陈好益)1; Fan GQ(范国钦)1; Li S(李石)1; Mao KB(毛可彬)1; Liu YH(刘元红)1
2014
Source PublicationTetrahedron Lett.
Volume55Issue:9Pages:1593-1596
AbstractThe reaction of imines with low-valent titanium species, generated in situ by using Ti((OPr)-Pr-i)(4)/2 c-O5H9-MgCI reagent, affords titanium-imine complex, which can couple with nitriles to provide 2,5-diazatitanacyclopentenes. alpha-Aminoketones are obtained in good yields by quenching the corresponding 2,5-diazatitanacyclopentenes with aqueous HC1 solution. However, when the reaction is first quenched with MeOH in air followed by addition of aqueous HCl solution, 1,2-diketones are formed in good to high yields. (c) 2014 Elsevier Ltd. All rights reserved.
Subject Area金属有机化学
DOI10.1016/j.tetlet.2014.01.070
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Indexed BySCI
Language英语
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Cited Times:5[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.sioc.ac.cn/handle/331003/39046
Collection金属有机化学国家重点实验室
Corresponding AuthorLiu YH(刘元红)
Affiliation1.中科院上海有机化学研究所
2.沈阳化工大学
Recommended Citation
GB/T 7714
Chen HY,Fan GQ,Li S,et al. Titanium-mediated reductive cross-coupling reactions of imines with nitriles: an efficient route for the synthesis of alpha-aminoketones or 1,2-diketones[J]. Tetrahedron Lett.,2014,55(9):1593-1596.
APA 陈好益,范国钦,李石,毛可彬,&刘元红.(2014).Titanium-mediated reductive cross-coupling reactions of imines with nitriles: an efficient route for the synthesis of alpha-aminoketones or 1,2-diketones.Tetrahedron Lett.,55(9),1593-1596.
MLA 陈好益,et al."Titanium-mediated reductive cross-coupling reactions of imines with nitriles: an efficient route for the synthesis of alpha-aminoketones or 1,2-diketones".Tetrahedron Lett. 55.9(2014):1593-1596.
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