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Pd-Catalyzed Intramolecular Aminohydroxylation of Alkenes with Hydrogen Peroxide as Oxidant and Water as Nucleophile
其他题名钯催化双氧水作为氧化剂, 水作为亲核试剂的烯烃的胺羟基化反应
Zhu HT(朱海涛); Chen PH(陈品红); Liu GS(刘国生)
2014
发表期刊J. Am. Chem. Soc.
卷号136期号:5页码:1766-1769
摘要A palladium-catalyzed intramolecular aminohydroxylation of alkenes was developed, in which H2O2 was applied as the sole oxidant. A variety of related alkyl alcohols could be successfully obtained with good yields and excellent diastereoselectivities, which directly derived from oxidation cleavage of alkyl C-Pd bond by H2O2. Facile transformation of these products provided a powerful tool toward the synthesis of 2-amino-1,3-diols and 3-ol amino acids. Preliminary mechanistic studies revealed that major nucleophilic attack of water (S(N)2 type) at high-valent Pd center contributes to the final C-O(H) bond formation.
学科领域金属有机化学
DOI10.1021/ja412023b
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收录类别SCI
语种英语
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文献类型期刊论文
条目标识符http://ir.sioc.ac.cn/handle/331003/39035
专题金属有机化学国家重点实验室
通讯作者Liu GS(刘国生)
作者单位中科院上海有机化学研究所
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GB/T 7714
Zhu HT,Chen PH,Liu GS. Pd-Catalyzed Intramolecular Aminohydroxylation of Alkenes with Hydrogen Peroxide as Oxidant and Water as Nucleophile[J]. J. Am. Chem. Soc.,2014,136(5):1766-1769.
APA 朱海涛,陈品红,&刘国生.(2014).Pd-Catalyzed Intramolecular Aminohydroxylation of Alkenes with Hydrogen Peroxide as Oxidant and Water as Nucleophile.J. Am. Chem. Soc.,136(5),1766-1769.
MLA 朱海涛,et al."Pd-Catalyzed Intramolecular Aminohydroxylation of Alkenes with Hydrogen Peroxide as Oxidant and Water as Nucleophile".J. Am. Chem. Soc. 136.5(2014):1766-1769.
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