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学科主题: 金属有机化学
题名: Pd-Catalyzed Intramolecular Aminohydroxylation of Alkenes with Hydrogen Peroxide as Oxidant and Water as Nucleophile
其他题名: 钯催化双氧水作为氧化剂, 水作为亲核试剂的烯烃的胺羟基化反应
作者: Zhu HT(朱海涛); Chen PH(陈品红); Liu GS(刘国生)
通讯作者: 刘国生
刊名: J. Am. Chem. Soc.
发表日期: 2014
DOI: 10.1021/ja412023b
卷: 136, 期:5, 页:1766-1769
收录类别: SCI
英文摘要: A palladium-catalyzed intramolecular aminohydroxylation of alkenes was developed, in which H2O2 was applied as the sole oxidant. A variety of related alkyl alcohols could be successfully obtained with good yields and excellent diastereoselectivities, which directly derived from oxidation cleavage of alkyl C-Pd bond by H2O2. Facile transformation of these products provided a powerful tool toward the synthesis of 2-amino-1,3-diols and 3-ol amino acids. Preliminary mechanistic studies revealed that major nucleophilic attack of water (S(N)2 type) at high-valent Pd center contributes to the final C-O(H) bond formation.
语种: 英语
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内容类型: 期刊论文
URI标识: http://ir.sioc.ac.cn/handle/331003/39035
Appears in Collections:金属有机化学国家重点实验室_期刊论文

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作者单位: 中科院上海有机化学研究所

Recommended Citation:
Zhu HT,Chen PH,Liu GS. Pd-Catalyzed Intramolecular Aminohydroxylation of Alkenes with Hydrogen Peroxide as Oxidant and Water as Nucleophile[J]. J. Am. Chem. Soc.,2014,136(5):1766-1769.
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