SIOC OpenIR  > 金属有机化学国家重点实验室
Pd-Catalyzed Intramolecular Aminohydroxylation of Alkenes with Hydrogen Peroxide as Oxidant and Water as Nucleophile
Alternative Title钯催化双氧水作为氧化剂, 水作为亲核试剂的烯烃的胺羟基化反应
Zhu HT(朱海涛); Chen PH(陈品红); Liu GS(刘国生)
2014
Source PublicationJ. Am. Chem. Soc.
Volume136Issue:5Pages:1766-1769
AbstractA palladium-catalyzed intramolecular aminohydroxylation of alkenes was developed, in which H2O2 was applied as the sole oxidant. A variety of related alkyl alcohols could be successfully obtained with good yields and excellent diastereoselectivities, which directly derived from oxidation cleavage of alkyl C-Pd bond by H2O2. Facile transformation of these products provided a powerful tool toward the synthesis of 2-amino-1,3-diols and 3-ol amino acids. Preliminary mechanistic studies revealed that major nucleophilic attack of water (S(N)2 type) at high-valent Pd center contributes to the final C-O(H) bond formation.
Subject Area金属有机化学
DOI10.1021/ja412023b
URL查看原文
Indexed BySCI
Language英语
Citation statistics
Cited Times:71[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.sioc.ac.cn/handle/331003/39035
Collection金属有机化学国家重点实验室
Corresponding AuthorLiu GS(刘国生)
Affiliation中科院上海有机化学研究所
Recommended Citation
GB/T 7714
Zhu HT,Chen PH,Liu GS. Pd-Catalyzed Intramolecular Aminohydroxylation of Alkenes with Hydrogen Peroxide as Oxidant and Water as Nucleophile[J]. J. Am. Chem. Soc.,2014,136(5):1766-1769.
APA 朱海涛,陈品红,&刘国生.(2014).Pd-Catalyzed Intramolecular Aminohydroxylation of Alkenes with Hydrogen Peroxide as Oxidant and Water as Nucleophile.J. Am. Chem. Soc.,136(5),1766-1769.
MLA 朱海涛,et al."Pd-Catalyzed Intramolecular Aminohydroxylation of Alkenes with Hydrogen Peroxide as Oxidant and Water as Nucleophile".J. Am. Chem. Soc. 136.5(2014):1766-1769.
Files in This Item:
File Name/Size DocType Version Access License
2014087.pdf(302KB)期刊论文作者接受稿开放获取CC BY-NC-SAApplication Full Text
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[朱海涛]'s Articles
[陈品红]'s Articles
[刘国生]'s Articles
Baidu academic
Similar articles in Baidu academic
[朱海涛]'s Articles
[陈品红]'s Articles
[刘国生]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[朱海涛]'s Articles
[陈品红]'s Articles
[刘国生]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.