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学科主题: 金属有机化学
题名: Efficient Syntheses of Korupensamines A, B and Michellamine B by Asymmetric Suzuki-Miyaura Coupling Reactions
其他题名: 通过不对称Suzuki-Miyaura偶联高效合成Korupensamine A,B, 以及 Michellamine B
作者: Xu GQ(徐广庆)1; Fu WZ(付文振)1; Liu GD(刘国都)1; SENANAYAKE CHRIS H1; Tang WJ(汤文军)1
通讯作者: 汤文军
刊名: J. Am. Chem. Soc.
发表日期: 2014
DOI: 10.1021/ja409669r
卷: 136, 期:2, 页:570-573
收录类别: SCI
英文摘要: Efficient asymmetric Suzuki-Miyaura coupling reactions are employed for the first time in total syntheses of chiral biaryl natural products korupensamine A and B in combination with an effective diastereoselective hydrogenation, allowing ultimately a concise and stereoselective synthesis of michellamine B. Chiral monophosphorus ligands L1-3 are effective for the syntheses of a series of functionalized chiral biaryls by asymmetric Suzuki-Miyaura coupling reactions in excellent yields and enantioselectivities (up to 99% ee). The presence of a polar-pi interaction between the highly polarized BOP group and the extended pi system of arylboronic acid coupling partner is believed to be important for the high enantioselectivity.
语种: 英语
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内容类型: 期刊论文
URI标识: http://ir.sioc.ac.cn/handle/331003/39002
Appears in Collections:金属有机化学国家重点实验室_期刊论文

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作者单位: 1.中科院上海有机化学研究所
2.美国勃林格殷格翰制药公司

Recommended Citation:
Xu GQ,Fu WZ,Liu GD,et al. Efficient Syntheses of Korupensamines A, B and Michellamine B by Asymmetric Suzuki-Miyaura Coupling Reactions[J]. J. Am. Chem. Soc.,2014,136(2):570-573.
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