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学科主题: 金属有机化学
题名: SpinPhox/Iridium(I)-Catalyzed Asymmetric Hydrogenation of Cyclic alpha-Alkylidene Carbonyl Compounds
其他题名: SpinPhox/铱(I)催化环状alpha-亚烷基羰基化合物的不对称氢化
作者: Liu X(刘旭); Han ZB(韩召斌); Wang Z(王正); Ding KL(丁奎岭)
通讯作者: 丁奎岭
刊名: Angew. Chem.-Int. Edit.
发表日期: 2014
DOI: 10.1002/anie.201309521
卷: 53, 期:7, 页:1978-1982
收录类别: SCI
英文摘要: Optically active medium-sized cyclic carbonyl compounds bearing an -chiral carbon center are of interest in pharmaceutical sciences and asymmetric synthesis. Herein, SpinPhox/Ir-I catalysts have been demonstrated to be highly enantioselective in the asymmetric hydrogenation of the CC bonds in the exocyclic ,-unsaturated cyclic carbonyls, including a broad range of -alkylidene lactams, unsaturated cyclic ketones, and lactones. It is noteworthy that the procedure can be successfully used in the asymmetric hydrogenation of the challenging -alkylidenelactam substrates with six- or seven-membered rings, thus affording the corresponding optically active carbonyl compounds with an -chiral carbon center in generally excellent enantiomeric excesses (up to 98%ee). Synthetic utility of the protocol has also been demonstrated in the asymmetric synthesis of the anti-inflammatory drug loxoprofen and its analogue, as well as biologically important epsilon-aminocaproic acid derivatives.
语种: 英语
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内容类型: 期刊论文
URI标识: http://ir.sioc.ac.cn/handle/331003/38998
Appears in Collections:金属有机化学国家重点实验室_期刊论文

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作者单位: 中科院上海有机化学研究所

Recommended Citation:
Liu X,Han ZB,Wang Z,et al. SpinPhox/Iridium(I)-Catalyzed Asymmetric Hydrogenation of Cyclic alpha-Alkylidene Carbonyl Compounds[J]. Angew. Chem.-Int. Edit.,2014,53(7):1978-1982.
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