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学科主题: 天然产物有机化学
题名: Tunable Arylative Cyclization of 1,6-Enynes Triggered by Rhodium(III)-Catalyzed C-H Activation
其他题名: Tunable Arylative Cyclization of 1,6-Enynes Triggered by Rhodium(III)-Catalyzed C-H Activation
作者: 福井雄树; Liu P(刘平); He ZT(何智涛); Wu NY(吴诺毅); Tian P(田平); Lin GQ(林国强)
通讯作者: 田平 ; 林国强
刊名: J. Am. Chem. Soc.
发表日期: 2014
DOI: 10.1021/ja5072702
卷: 136, 期:44, 页:15607-15614
收录类别: SCI
英文摘要: Two tunable arylative cyclizations of cyclohexadienone-containing 1,6-enynes are reported via rhodium(III)-catalyzed C-H activation of O-substituted N-hydroxybenzamides. The use of different O substituents, i.e. O-Piv and O-Me, on the directing group allows the formation of either tetracyclic isoquinolones through an (c)-Michael addition process or hydrobenzofurans through a (N)Michael addition process. Mechanistic investigations of these two cascade reactions clearly indicated that the C-H bond cleavage process was involved in the turnover-limiting step. Furthermore, the cyclization products could be subjected to various transformations for elaborating the pharmaceutically and synthetically valuable potential. This is the first example of a rhodium(III)-catalyzed arylative cyclization reaction of 1,6-enynes, and the results extend the application realm of Cp*Rh-III-catalyzed C-H activation cascade reactions.
语种: 英语
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内容类型: 期刊论文
URI标识: http://ir.sioc.ac.cn/handle/331003/38993
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作者单位: 中科院上海有机化学研究所

Recommended Citation:
福井雄树,Liu P,He ZT,et al. Tunable Arylative Cyclization of 1,6-Enynes Triggered by Rhodium(III)-Catalyzed C-H Activation[J]. J. Am. Chem. Soc.,2014,136(44):15607-15614.
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