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Highly Efficient and Scalable Synthesis of Clionamine D
Alternative TitleHighly Efficient and Scalable Synthesis of Clionamine D
Wang SS(王莎莎); Shi Y(史勇); Tian WS(田伟生)
2014
Source PublicationOrg. Lett.
Volume16Issue:8Pages:2177-2179
AbstractHerein we describe an efficient and scalable synthesis of clionamine D (4), a special member with autophagy bioactivity and an unprecedented spirobislactone side chain in the novel aminosteroid clionamines. This synthesis features a quick access to alpha-methylene-gamma-lactone 8 and a Mn(OAc)(3)-mediated radical [3 + 2] reaction to assemble the unique spirobislactone unit. Clionamine D (4) can also serve as a key synthetic precursor to other clionamine members.
Subject Area天然产物有机化学
DOI10.1021/ol500727c
URL查看原文
Indexed BySCI
Language英语
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Document Type期刊论文
Identifierhttp://ir.sioc.ac.cn/handle/331003/38980
Collection中科院天然产物有机化学重点实验室
Corresponding AuthorShi Y(史勇); Tian WS(田伟生)
Affiliation中科院上海有机化学研究所
Recommended Citation
GB/T 7714
Wang SS,Shi Y,Tian WS. Highly Efficient and Scalable Synthesis of Clionamine D[J]. Org. Lett.,2014,16(8):2177-2179.
APA 王莎莎,史勇,&田伟生.(2014).Highly Efficient and Scalable Synthesis of Clionamine D.Org. Lett.,16(8),2177-2179.
MLA 王莎莎,et al."Highly Efficient and Scalable Synthesis of Clionamine D".Org. Lett. 16.8(2014):2177-2179.
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