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抗体药物偶联物
Alternative TitleAntibody-Drug Conjugates
曹刚1; 黄祚刚1; 程杰飞1; 姜标1
2014
Source PublicationProg. Chem.
Volume26Issue:2-3Pages:467-477
Other AbstractOver 35 monoclonal antibody drugs have been marketed since the approval of first monoclonal antibody drug in 1986, making the antibody drug development one of the most exciting fields. Antibody-drug conjugate (ADC), which combines a monoclonal antibody (mAb) with a cytotoxic (drug) molecule through a linker and thereby the name, is a new class of highly potent biopharmaceutical drugs designed as a targeted therapy. ADC takes advantage of the high binding specificity of mAbs and superior efficacy of cytotoxic molecules, while avoiding the dose-limiting toxicity of cytotoxic molecules. The first ADC, Mylotarg, was approved in 2000, which was late withdrawn by the manufacture due to the lack of appropriate stability of the linker. So far, there are two approved ADCs in the market for cancer therapy and over twenty ADCs in various stages of clinical trials. Creating a successful antibody drug conjugate requires careful selection of the drug, antibody and linker. Linker has a great influence on a conjugate' s biological characteristics, such as stability in circulation and drug release at the target site. ADCs have been proven to be effective weapons against cancers and will certainly become useful therapeutics against other diseases.
Subject Area天然产物有机化学
DOI10.7536/PC130650
URL查看原文
Indexed BySCI
Language中文
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Document Type期刊论文
Identifierhttp://ir.sioc.ac.cn/handle/331003/38978
Collection中科院天然产物有机化学重点实验室
Corresponding Author程杰飞; 姜标
Affiliation1.中科院上海高等研究院
2.大冢(上海)药物研究开发有限公司
3.中科院上海有机化学研究所
4.上海科技大学
Recommended Citation
GB/T 7714
曹刚,黄祚刚,程杰飞,等. 抗体药物偶联物[J]. Prog. Chem.,2014,26(2-3):467-477.
APA 曹刚,黄祚刚,程杰飞,&姜标.(2014).抗体药物偶联物.Prog. Chem.,26(2-3),467-477.
MLA 曹刚,et al."抗体药物偶联物".Prog. Chem. 26.2-3(2014):467-477.
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