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Copper-Catalyzed Asymmetric Hydroboration of alpha-Dehydroamino Acid Derivatives: Facile Synthesis of Chiral beta-Hydroxy-alpha-amino Acids
Alternative TitleCopper-Catalyzed Asymmetric Hydroboration of alpha-Dehydroamino Acid Derivatives: Facile Synthesis of Chiral beta-Hydroxy-alpha-amino Acids
He ZT(何智涛); Zhao YS(赵一爽); Tian P(田平); Wang CC(王川川); Dong HQ(董汉清); Lin GQ(林国强)
2014
Source PublicationOrg. Lett.
Volume16Issue:5Pages:1426-1429
AbstractThe Cu-catalyzed asymmetric conjugate hydroboration reaction of beta-substituted alpha-dehydroamino acid derivatives has been established, affording enantioenriched syn- and anti-beta-boronate-alpha-amino acid derivatives with excellent combined yields (83-99%, dr approximate to 1:1) and excellent enantioselectivities (92-98% ee). The hydroboration products were expediently converted into valuable beta-hydroxy-alpha-amino acid derivatives, which were widely used in the preparation of chiral drugs and bioactive molecules.
Subject Area天然产物有机化学
DOI10.1021/ol500219e
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Indexed BySCI
Language英语
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Document Type期刊论文
Identifierhttp://ir.sioc.ac.cn/handle/331003/38974
Collection中科院天然产物有机化学重点实验室
Corresponding AuthorTian P(田平); Lin GQ(林国强)
Affiliation中科院上海有机化学研究所
Recommended Citation
GB/T 7714
He ZT,Zhao YS,Tian P,et al. Copper-Catalyzed Asymmetric Hydroboration of alpha-Dehydroamino Acid Derivatives: Facile Synthesis of Chiral beta-Hydroxy-alpha-amino Acids[J]. Org. Lett.,2014,16(5):1426-1429.
APA 何智涛,赵一爽,田平,王川川,董汉清,&林国强.(2014).Copper-Catalyzed Asymmetric Hydroboration of alpha-Dehydroamino Acid Derivatives: Facile Synthesis of Chiral beta-Hydroxy-alpha-amino Acids.Org. Lett.,16(5),1426-1429.
MLA 何智涛,et al."Copper-Catalyzed Asymmetric Hydroboration of alpha-Dehydroamino Acid Derivatives: Facile Synthesis of Chiral beta-Hydroxy-alpha-amino Acids".Org. Lett. 16.5(2014):1426-1429.
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