Copper-Catalyzed Asymmetric Hydroboration of alpha-Dehydroamino Acid Derivatives: Facile Synthesis of Chiral beta-Hydroxy-alpha-amino Acids
其他题名Copper-Catalyzed Asymmetric Hydroboration of alpha-Dehydroamino Acid Derivatives: Facile Synthesis of Chiral beta-Hydroxy-alpha-amino Acids
He ZT(何智涛); Zhao YS(赵一爽); Tian P(田平); Wang CC(王川川); Dong HQ(董汉清); Lin GQ(林国强)
2014
发表期刊Org. Lett.
卷号16期号:5页码:1426-1429
摘要The Cu-catalyzed asymmetric conjugate hydroboration reaction of beta-substituted alpha-dehydroamino acid derivatives has been established, affording enantioenriched syn- and anti-beta-boronate-alpha-amino acid derivatives with excellent combined yields (83-99%, dr approximate to 1:1) and excellent enantioselectivities (92-98% ee). The hydroboration products were expediently converted into valuable beta-hydroxy-alpha-amino acid derivatives, which were widely used in the preparation of chiral drugs and bioactive molecules.
学科领域天然产物有机化学
DOI10.1021/ol500219e
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收录类别SCI
语种英语
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被引频次:46[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.sioc.ac.cn/handle/331003/38974
专题中科院天然产物有机化学重点实验室
通讯作者Tian P(田平); Lin GQ(林国强)
作者单位中科院上海有机化学研究所
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GB/T 7714
He ZT,Zhao YS,Tian P,et al. Copper-Catalyzed Asymmetric Hydroboration of alpha-Dehydroamino Acid Derivatives: Facile Synthesis of Chiral beta-Hydroxy-alpha-amino Acids[J]. Org. Lett.,2014,16(5):1426-1429.
APA 何智涛,赵一爽,田平,王川川,董汉清,&林国强.(2014).Copper-Catalyzed Asymmetric Hydroboration of alpha-Dehydroamino Acid Derivatives: Facile Synthesis of Chiral beta-Hydroxy-alpha-amino Acids.Org. Lett.,16(5),1426-1429.
MLA 何智涛,et al."Copper-Catalyzed Asymmetric Hydroboration of alpha-Dehydroamino Acid Derivatives: Facile Synthesis of Chiral beta-Hydroxy-alpha-amino Acids".Org. Lett. 16.5(2014):1426-1429.
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