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学科主题: 天然产物有机化学
题名: Copper-Catalyzed Asymmetric Hydroboration of alpha-Dehydroamino Acid Derivatives: Facile Synthesis of Chiral beta-Hydroxy-alpha-amino Acids
其他题名: Copper-Catalyzed Asymmetric Hydroboration of alpha-Dehydroamino Acid Derivatives: Facile Synthesis of Chiral beta-Hydroxy-alpha-amino Acids
作者: He ZT(何智涛); Zhao YS(赵一爽); Tian P(田平); Wang CC(王川川); Dong HQ(董汉清); Lin GQ(林国强)
通讯作者: 田平 ; 林国强
刊名: Org. Lett.
发表日期: 2014
DOI: 10.1021/ol500219e
卷: 16, 期:5, 页:1426-1429
收录类别: SCI
英文摘要: The Cu-catalyzed asymmetric conjugate hydroboration reaction of beta-substituted alpha-dehydroamino acid derivatives has been established, affording enantioenriched syn- and anti-beta-boronate-alpha-amino acid derivatives with excellent combined yields (83-99%, dr approximate to 1:1) and excellent enantioselectivities (92-98% ee). The hydroboration products were expediently converted into valuable beta-hydroxy-alpha-amino acid derivatives, which were widely used in the preparation of chiral drugs and bioactive molecules.
语种: 英语
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内容类型: 期刊论文
URI标识: http://ir.sioc.ac.cn/handle/331003/38974
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作者单位: 中科院上海有机化学研究所

Recommended Citation:
He ZT,Zhao YS,Tian P,et al. Copper-Catalyzed Asymmetric Hydroboration of alpha-Dehydroamino Acid Derivatives: Facile Synthesis of Chiral beta-Hydroxy-alpha-amino Acids[J]. Org. Lett.,2014,16(5):1426-1429.
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