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Total synthesis of (S)-14-azacamptothecin
Alternative Title14-氮杂喜树碱的全合成
Liu F(刘峰)1; Li CZ(李超忠)1
2014
Source PublicationOrg. Biomol. Chem.
Volume12Issue:4Pages:637-642
AbstractA concise synthesis of (S)-14-azacamptothecin has been accomplished in 8 steps from commercially available (R)-2-hydroxybutanoic acid. The key strategy involved in this synthesis is the Michael addition/beta-elimination sequence to construct the chiral quaternary carbon center, followed by palladium catalyzed cyanation and formal [4 + 2] cycloaddition/elimination/aromatization in a one pot manner to form the pyrrolopyrimidin-4-one moiety.
Subject Area天然产物有机化学
DOI10.1039/c3ob41883a
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Indexed BySCI
Language英语
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Document Type期刊论文
Identifierhttp://ir.sioc.ac.cn/handle/331003/38968
Collection中科院天然产物有机化学重点实验室
Corresponding AuthorLiu F(刘峰)
Affiliation1.苏州大学
2.中科院上海有机化学研究所
Recommended Citation
GB/T 7714
Liu F,Li CZ. Total synthesis of (S)-14-azacamptothecin[J]. Org. Biomol. Chem.,2014,12(4):637-642.
APA 刘峰,&李超忠.(2014).Total synthesis of (S)-14-azacamptothecin.Org. Biomol. Chem.,12(4),637-642.
MLA 刘峰,et al."Total synthesis of (S)-14-azacamptothecin".Org. Biomol. Chem. 12.4(2014):637-642.
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