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学科主题: 天然产物有机化学
题名: Total synthesis of (S)-14-azacamptothecin
其他题名: 14-氮杂喜树碱的全合成
作者: Liu F(刘峰)1; Li CZ(李超忠)1
通讯作者: 刘峰
刊名: Org. Biomol. Chem.
发表日期: 2014
DOI: 10.1039/c3ob41883a
卷: 12, 期:4, 页:637-642
收录类别: SCI
英文摘要: A concise synthesis of (S)-14-azacamptothecin has been accomplished in 8 steps from commercially available (R)-2-hydroxybutanoic acid. The key strategy involved in this synthesis is the Michael addition/beta-elimination sequence to construct the chiral quaternary carbon center, followed by palladium catalyzed cyanation and formal [4 + 2] cycloaddition/elimination/aromatization in a one pot manner to form the pyrrolopyrimidin-4-one moiety.
语种: 英语
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内容类型: 期刊论文
URI标识: http://ir.sioc.ac.cn/handle/331003/38968
Appears in Collections:中科院天然产物有机化学重点实验室_期刊论文

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作者单位: 1.苏州大学
2.中科院上海有机化学研究所

Recommended Citation:
Liu F,Li CZ. Total synthesis of (S)-14-azacamptothecin[J]. Org. Biomol. Chem.,2014,12(4):637-642.
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