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学科主题: 生命有机化学
题名: The PHD1 finger of KDM5B recognizes unmodified H3K4 during the demethylation of histone H3K4me2/3 by KDM5B
其他题名: The PHD1 finger of KDM5B recognizes unmodified H3K4 during the demethylation of histone H3K4me2/3 by KDM5B
作者: Zhang Y(张岩)1; YANG HUIRONG1; GUO XUE1; RONG NAIYAN1; SONG YUJIAO1; XU YOUWEI1; LAN WENXIAN1; ZHANG XU1; LIU MAILI1; XU YANHUI1; Cao CY(曹春阳)1
通讯作者: XU YANHUI ; 曹春阳
刊名: Protein Cell
发表日期: 2014
DOI: 10.1007/s13238-014-0078-4
卷: 5, 期:11, 页:837-850
收录类别: SCI
英文摘要: KDM5B is a histone H3K4me2/3 demethylase. The PHD1 domain of KDM5B is critical for demethylation, but the mechanism underlying the action of this domain is unclear. In this paper, we observed that PHD1(KDM5B) interacts with unmethylated H3K4me0. Our NMR structure of PHD1(KDM5B) in complex with H3K4me0 revealed that the binding mode is slightly different from that of other reported PHD fingers. The disruption of this interaction by double mutations on the residues in the interface (L325A/D328A) decreases the H3K4me2/3 demethylation activity of KDM5B in cells by approximately 50% and increases the transcriptional repression of tumor suppressor genes by approximately twofold. These findings imply that PHD1(KDM5B) may help maintain KDM5B at target genes to mediate the demethylation activities of KDM5B.
语种: 英语
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内容类型: 期刊论文
URI标识: http://ir.sioc.ac.cn/handle/331003/38962
Appears in Collections:生命有机化学国家重点实验室_期刊论文

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作者单位: 1.中科院上海有机化学研究所
2.复旦大学
3.中科院武汉物理与数学研究所

Recommended Citation:
Zhang Y,YANG HUIRONG,GUO XUE,et al. The PHD1 finger of KDM5B recognizes unmodified H3K4 during the demethylation of histone H3K4me2/3 by KDM5B[J]. Protein Cell,2014,5(11):837-850.
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