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An Unusual Dehydratase Acting on Glycerate and a Ketoreducatse Stereoselectively Reducing alpha-Ketone in Polyketide Starter Unit Biosynthesis
Alternative Title聚酮起始单元生物合成中一个新的脱水酶作用于甘油底物及酮基还原酶立体选择性还原a-酮基
He HY(贺海燕)1; Yuan H(袁华)1; Tang MC(唐满成)1; Tang GL(唐功利)1
2014
Source PublicationAngew. Chem.-Int. Edit.
Volume53Issue:42Pages:11315-11319
AbstractPolyketide synthases (PKSs) usually employ a ketoreductase (KR) to catalyze the reduction of a -keto group, followed by a dehydratase (DH) that drives the dehydration to form a double bond between the - and -carbon atoms. Herein, a DH*-KR* involved in FR901464 biosynthesis was characterized: DH* acts on glyceryl-S-acyl carrier protein (ACP) to yield ACP-linked pyruvate; subsequently KR* reduces -ketone that yields L-lactyl-S-ACP as starter unit for polyketide biosynthesis. Genetic and biochemical evidence was found to support a similar pathway that is involved in the biosynthesis of lankacidins. These results not only identified new PKS domains acting on different substrates, but also provided additional options for engineering the PKS starter pathway or biocatalysis.
Subject Area生命有机化学
DOI10.1002/anie.201406602
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Indexed BySCI
Language英语
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Document Type期刊论文
Identifierhttp://ir.sioc.ac.cn/handle/331003/38960
Collection生命有机化学国家重点实验室
Corresponding AuthorTang GL(唐功利)
Affiliation1.中科院上海有机化学研究所
2.上海生物制造技术协同创新中心
Recommended Citation
GB/T 7714
He HY,Yuan H,Tang MC,et al. An Unusual Dehydratase Acting on Glycerate and a Ketoreducatse Stereoselectively Reducing alpha-Ketone in Polyketide Starter Unit Biosynthesis[J]. Angew. Chem.-Int. Edit.,2014,53(42):11315-11319.
APA 贺海燕,袁华,唐满成,&唐功利.(2014).An Unusual Dehydratase Acting on Glycerate and a Ketoreducatse Stereoselectively Reducing alpha-Ketone in Polyketide Starter Unit Biosynthesis.Angew. Chem.-Int. Edit.,53(42),11315-11319.
MLA 贺海燕,et al."An Unusual Dehydratase Acting on Glycerate and a Ketoreducatse Stereoselectively Reducing alpha-Ketone in Polyketide Starter Unit Biosynthesis".Angew. Chem.-Int. Edit. 53.42(2014):11315-11319.
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