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学科主题: 生命有机化学
题名: An Unusual Dehydratase Acting on Glycerate and a Ketoreducatse Stereoselectively Reducing alpha-Ketone in Polyketide Starter Unit Biosynthesis
其他题名: 聚酮起始单元生物合成中一个新的脱水酶作用于甘油底物及酮基还原酶立体选择性还原a-酮基
作者: He HY(贺海燕)1; Yuan H(袁华)1; Tang MC(唐满成)1; Tang GL(唐功利)1
通讯作者: 唐功利
刊名: Angew. Chem.-Int. Edit.
发表日期: 2014
DOI: 10.1002/anie.201406602
卷: 53, 期:42, 页:11315-11319
收录类别: SCI
英文摘要: Polyketide synthases (PKSs) usually employ a ketoreductase (KR) to catalyze the reduction of a -keto group, followed by a dehydratase (DH) that drives the dehydration to form a double bond between the - and -carbon atoms. Herein, a DH*-KR* involved in FR901464 biosynthesis was characterized: DH* acts on glyceryl-S-acyl carrier protein (ACP) to yield ACP-linked pyruvate; subsequently KR* reduces -ketone that yields L-lactyl-S-ACP as starter unit for polyketide biosynthesis. Genetic and biochemical evidence was found to support a similar pathway that is involved in the biosynthesis of lankacidins. These results not only identified new PKS domains acting on different substrates, but also provided additional options for engineering the PKS starter pathway or biocatalysis.
语种: 英语
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内容类型: 期刊论文
URI标识: http://ir.sioc.ac.cn/handle/331003/38960
Appears in Collections:生命有机化学国家重点实验室_期刊论文

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作者单位: 1.中科院上海有机化学研究所
2.上海生物制造技术协同创新中心

Recommended Citation:
He HY,Yuan H,Tang MC,et al. An Unusual Dehydratase Acting on Glycerate and a Ketoreducatse Stereoselectively Reducing alpha-Ketone in Polyketide Starter Unit Biosynthesis[J]. Angew. Chem.-Int. Edit.,2014,53(42):11315-11319.
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