SIOC OpenIR  > 生命有机化学国家重点实验室
Total synthesis of proposed structure of coibamide A, a highly N- and O-methylated cytotoxic marine cyclodepsipeptide
Alternative TitleTotal synthesis of proposed structure of coibamide A, a highly N- and O-methylated cytotoxic marine cyclodepsipeptide
He W(何伟)1; Qiu HB(邱海波)1; Chen YJ(陈漪洁)1; Yao ZJ(姚祝军)1
2014
Source PublicationTetrahedron Lett.
Volume55Issue:44Pages:6109-6112
AbstractTotal synthesis of the originally proposed structure of coibamide A, a highly N- and O-methylated cytotoxic marine cyclodepsipeptide, has been accomplished by using a [(4+1)+3+3]-peptide fragment-coupling strategy and careful examination and optimization of the multiple dense N-methylated amide-bond formations. The synthetic sample of the proposed coibamide A could not match the natural product in both H-1 and C-13 NMR spectra, but was found to exhibit low micromolar cytotoxicity against the proliferation of three tested cancer cells. (C) 2014 Elsevier Ltd. All rights reserved.
Subject Area生命有机化学
DOI10.1016/j.tetlet.2014.09.047
URL查看原文
Indexed BySCI
Language英语
Citation statistics
Document Type期刊论文
Identifierhttp://ir.sioc.ac.cn/handle/331003/38959
Collection生命有机化学国家重点实验室
Corresponding AuthorYao ZJ(姚祝军)
Affiliation1.中科院上海有机化学研究所
2.南京大学
Recommended Citation
GB/T 7714
He W,Qiu HB,Chen YJ,et al. Total synthesis of proposed structure of coibamide A, a highly N- and O-methylated cytotoxic marine cyclodepsipeptide[J]. Tetrahedron Lett.,2014,55(44):6109-6112.
APA 何伟,邱海波,陈漪洁,&姚祝军.(2014).Total synthesis of proposed structure of coibamide A, a highly N- and O-methylated cytotoxic marine cyclodepsipeptide.Tetrahedron Lett.,55(44),6109-6112.
MLA 何伟,et al."Total synthesis of proposed structure of coibamide A, a highly N- and O-methylated cytotoxic marine cyclodepsipeptide".Tetrahedron Lett. 55.44(2014):6109-6112.
Files in This Item:
File Name/Size DocType Version Access License
2014492.pdf(866KB)期刊论文作者接受稿开放获取CC BY-NC-SAApplication Full Text
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[何伟]'s Articles
[邱海波]'s Articles
[陈漪洁]'s Articles
Baidu academic
Similar articles in Baidu academic
[何伟]'s Articles
[邱海波]'s Articles
[陈漪洁]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[何伟]'s Articles
[邱海波]'s Articles
[陈漪洁]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.