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Total synthesis of proposed structure of coibamide A, a highly N- and O-methylated cytotoxic marine cyclodepsipeptide
其他题名Total synthesis of proposed structure of coibamide A, a highly N- and O-methylated cytotoxic marine cyclodepsipeptide
He W(何伟)1; Qiu HB(邱海波)1; Chen YJ(陈漪洁)1; Yao ZJ(姚祝军)1
2014
发表期刊Tetrahedron Lett.
卷号55期号:44页码:6109-6112
摘要Total synthesis of the originally proposed structure of coibamide A, a highly N- and O-methylated cytotoxic marine cyclodepsipeptide, has been accomplished by using a [(4+1)+3+3]-peptide fragment-coupling strategy and careful examination and optimization of the multiple dense N-methylated amide-bond formations. The synthetic sample of the proposed coibamide A could not match the natural product in both H-1 and C-13 NMR spectra, but was found to exhibit low micromolar cytotoxicity against the proliferation of three tested cancer cells. (C) 2014 Elsevier Ltd. All rights reserved.
学科领域生命有机化学
DOI10.1016/j.tetlet.2014.09.047
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收录类别SCI
语种英语
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被引频次:10[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.sioc.ac.cn/handle/331003/38959
专题生命有机化学国家重点实验室
通讯作者Yao ZJ(姚祝军)
作者单位1.中科院上海有机化学研究所
2.南京大学
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He W,Qiu HB,Chen YJ,et al. Total synthesis of proposed structure of coibamide A, a highly N- and O-methylated cytotoxic marine cyclodepsipeptide[J]. Tetrahedron Lett.,2014,55(44):6109-6112.
APA 何伟,邱海波,陈漪洁,&姚祝军.(2014).Total synthesis of proposed structure of coibamide A, a highly N- and O-methylated cytotoxic marine cyclodepsipeptide.Tetrahedron Lett.,55(44),6109-6112.
MLA 何伟,et al."Total synthesis of proposed structure of coibamide A, a highly N- and O-methylated cytotoxic marine cyclodepsipeptide".Tetrahedron Lett. 55.44(2014):6109-6112.
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