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学科主题: 生命有机化学
题名: Total synthesis of proposed structure of coibamide A, a highly N- and O-methylated cytotoxic marine cyclodepsipeptide
其他题名: Total synthesis of proposed structure of coibamide A, a highly N- and O-methylated cytotoxic marine cyclodepsipeptide
作者: He W(何伟)1; Qiu HB(邱海波)1; Chen YJ(陈漪洁)1; Yao ZJ(姚祝军)1
通讯作者: 姚祝军
刊名: Tetrahedron Lett.
发表日期: 2014
DOI: 10.1016/j.tetlet.2014.09.047
卷: 55, 期:44, 页:6109-6112
收录类别: SCI
英文摘要: Total synthesis of the originally proposed structure of coibamide A, a highly N- and O-methylated cytotoxic marine cyclodepsipeptide, has been accomplished by using a [(4+1)+3+3]-peptide fragment-coupling strategy and careful examination and optimization of the multiple dense N-methylated amide-bond formations. The synthetic sample of the proposed coibamide A could not match the natural product in both H-1 and C-13 NMR spectra, but was found to exhibit low micromolar cytotoxicity against the proliferation of three tested cancer cells. (C) 2014 Elsevier Ltd. All rights reserved.
语种: 英语
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内容类型: 期刊论文
URI标识: http://ir.sioc.ac.cn/handle/331003/38959
Appears in Collections:生命有机化学国家重点实验室_期刊论文

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作者单位: 1.中科院上海有机化学研究所
2.南京大学

Recommended Citation:
He W,Qiu HB,Chen YJ,et al. Total synthesis of proposed structure of coibamide A, a highly N- and O-methylated cytotoxic marine cyclodepsipeptide[J]. Tetrahedron Lett.,2014,55(44):6109-6112.
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