SIOC OpenIR  > 生命有机化学国家重点实验室
Unified flexible total synthesis of chlorofusin and artificial Click mimics as antagonists against p53-HDM2 interactions
Alternative TitleUnified flexible total synthesis of chlorofusin and artificial Click mimics as antagonists against p53-HDM2 interactions
Qiu HB(邱海波); Chen XY(陈新雅); Li Q(李晴); Qian WJ(钱文建); Yu SM(于顺明); Tang GL(唐功利); Yao ZJ(姚祝军)
2014
Source PublicationTetrahedron Lett.
Volume55Issue:44Pages:6055-6059
AbstractA practical HPLC-free total synthesis of chlorofusin has been successfully accomplished in this work. The new synthesis showed great flexibility and convenience in generating artificial natural product-like mimics through Click chemistry, and enabled us to further investigate the biological importance of the chromophore and the spiro-aminal functionality of the natural product. The entire skeleton is believed to be essential for satisfactory biological activities of both natural chlorofusin and unnatural mimics. Two artificial Click hybrids were found to exhibit improved inhibitory activity against p53-HDM2 bindings over the natural product. (C) 2014 Elsevier Ltd. All rights reserved.
Subject Area生命有机化学
DOI10.1016/j.tetlet.2014.09.028
URL查看原文
Indexed BySCI
Language英语
Citation statistics
Document Type期刊论文
Identifierhttp://ir.sioc.ac.cn/handle/331003/38958
Collection生命有机化学国家重点实验室
Corresponding AuthorTang GL(唐功利); Yao ZJ(姚祝军)
Affiliation中科院上海有机化学研究所
Recommended Citation
GB/T 7714
Qiu HB,Chen XY,Li Q,et al. Unified flexible total synthesis of chlorofusin and artificial Click mimics as antagonists against p53-HDM2 interactions[J]. Tetrahedron Lett.,2014,55(44):6055-6059.
APA 邱海波.,陈新雅.,李晴.,钱文建.,于顺明.,...&姚祝军.(2014).Unified flexible total synthesis of chlorofusin and artificial Click mimics as antagonists against p53-HDM2 interactions.Tetrahedron Lett.,55(44),6055-6059.
MLA 邱海波,et al."Unified flexible total synthesis of chlorofusin and artificial Click mimics as antagonists against p53-HDM2 interactions".Tetrahedron Lett. 55.44(2014):6055-6059.
Files in This Item:
File Name/Size DocType Version Access License
2014491.pdf(747KB)期刊论文作者接受稿开放获取CC BY-NC-SAApplication Full Text
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[邱海波]'s Articles
[陈新雅]'s Articles
[李晴]'s Articles
Baidu academic
Similar articles in Baidu academic
[邱海波]'s Articles
[陈新雅]'s Articles
[李晴]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[邱海波]'s Articles
[陈新雅]'s Articles
[李晴]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.