SIOC OpenIR  > 生命有机化学国家重点实验室
Unified flexible total synthesis of chlorofusin and artificial Click mimics as antagonists against p53-HDM2 interactions
其他题名Unified flexible total synthesis of chlorofusin and artificial Click mimics as antagonists against p53-HDM2 interactions
Qiu HB(邱海波); Chen XY(陈新雅); Li Q(李晴); Qian WJ(钱文建); Yu SM(于顺明); Tang GL(唐功利); Yao ZJ(姚祝军)
2014
发表期刊Tetrahedron Lett.
卷号55期号:44页码:6055-6059
摘要A practical HPLC-free total synthesis of chlorofusin has been successfully accomplished in this work. The new synthesis showed great flexibility and convenience in generating artificial natural product-like mimics through Click chemistry, and enabled us to further investigate the biological importance of the chromophore and the spiro-aminal functionality of the natural product. The entire skeleton is believed to be essential for satisfactory biological activities of both natural chlorofusin and unnatural mimics. Two artificial Click hybrids were found to exhibit improved inhibitory activity against p53-HDM2 bindings over the natural product. (C) 2014 Elsevier Ltd. All rights reserved.
学科领域生命有机化学
DOI10.1016/j.tetlet.2014.09.028
URL查看原文
收录类别SCI
语种英语
引用统计
被引频次:3[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.sioc.ac.cn/handle/331003/38958
专题生命有机化学国家重点实验室
通讯作者Tang GL(唐功利); Yao ZJ(姚祝军)
作者单位中科院上海有机化学研究所
推荐引用方式
GB/T 7714
Qiu HB,Chen XY,Li Q,et al. Unified flexible total synthesis of chlorofusin and artificial Click mimics as antagonists against p53-HDM2 interactions[J]. Tetrahedron Lett.,2014,55(44):6055-6059.
APA 邱海波.,陈新雅.,李晴.,钱文建.,于顺明.,...&姚祝军.(2014).Unified flexible total synthesis of chlorofusin and artificial Click mimics as antagonists against p53-HDM2 interactions.Tetrahedron Lett.,55(44),6055-6059.
MLA 邱海波,et al."Unified flexible total synthesis of chlorofusin and artificial Click mimics as antagonists against p53-HDM2 interactions".Tetrahedron Lett. 55.44(2014):6055-6059.
条目包含的文件
文件名称/大小 文献类型 版本类型 开放类型 使用许可
2014491.pdf(747KB)期刊论文作者接受稿开放获取CC BY-NC-SA请求全文
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[邱海波]的文章
[陈新雅]的文章
[李晴]的文章
百度学术
百度学术中相似的文章
[邱海波]的文章
[陈新雅]的文章
[李晴]的文章
必应学术
必应学术中相似的文章
[邱海波]的文章
[陈新雅]的文章
[李晴]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。