中国科学院上海有机化学研究所机构知识库
Advanced  
SIOC OpenIR  > 生命有机化学国家重点实验室  > 期刊论文
学科主题: 生命有机化学
题名: Unified flexible total synthesis of chlorofusin and artificial Click mimics as antagonists against p53-HDM2 interactions
其他题名: Unified flexible total synthesis of chlorofusin and artificial Click mimics as antagonists against p53-HDM2 interactions
作者: Qiu HB(邱海波); Chen XY(陈新雅); Li Q(李晴); Qian WJ(钱文建); Yu SM(于顺明); Tang GL(唐功利); Yao ZJ(姚祝军)
通讯作者: 唐功利 ; 姚祝军
刊名: Tetrahedron Lett.
发表日期: 2014
DOI: 10.1016/j.tetlet.2014.09.028
卷: 55, 期:44, 页:6055-6059
收录类别: SCI
英文摘要: A practical HPLC-free total synthesis of chlorofusin has been successfully accomplished in this work. The new synthesis showed great flexibility and convenience in generating artificial natural product-like mimics through Click chemistry, and enabled us to further investigate the biological importance of the chromophore and the spiro-aminal functionality of the natural product. The entire skeleton is believed to be essential for satisfactory biological activities of both natural chlorofusin and unnatural mimics. Two artificial Click hybrids were found to exhibit improved inhibitory activity against p53-HDM2 bindings over the natural product. (C) 2014 Elsevier Ltd. All rights reserved.
语种: 英语
相关网址: 查看原文
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.sioc.ac.cn/handle/331003/38958
Appears in Collections:生命有机化学国家重点实验室_期刊论文

Files in This Item: Download All
File Name/ File Size Content Type Version Access License
2014491.pdf(747KB)期刊论文作者接受稿开放获取View Download

作者单位: 中科院上海有机化学研究所

Recommended Citation:
Qiu HB,Chen XY,Li Q,et al. Unified flexible total synthesis of chlorofusin and artificial Click mimics as antagonists against p53-HDM2 interactions[J]. Tetrahedron Lett.,2014,55(44):6055-6059.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[邱海波]'s Articles
[陈新雅]'s Articles
[李晴]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[邱海波]‘s Articles
[陈新雅]‘s Articles
[李晴]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit
文件名: 2014491.pdf
格式: Adobe PDF
此文件暂不支持浏览
所有评论 (0)
暂无评论
 
评注功能仅针对注册用户开放,请您登录
您对该条目有什么异议,请填写以下表单,管理员会尽快联系您。
内 容:
Email:  *
单位:
验证码:   刷新
您在IR的使用过程中有什么好的想法或者建议可以反馈给我们。
标 题:
 *
内 容:
Email:  *
验证码:   刷新

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Powered by CSpace