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学科主题: 生命有机化学
题名: Discovery and efficient synthesis of a biologically active alkaloid inspired by thiostrepton biosynthesis
其他题名: 受硫链丝菌素生物合成的启发发现和高效合成具有生物活性的生物碱
作者: Zheng QF(郑庆飞)1; Wang SF(王守锋)1; Liu W(刘文)1
通讯作者: 刘文
刊名: Tetrahedron
发表日期: 2014
DOI: 10.1016/j.tet.2014.06.076
卷: 70, 期:42, 页:7686-7690
收录类别: SCI
英文摘要: Thiostrepton, a natural peptide macrocycle, is of great interest due to its structural complexity and numerous biological activities, including anti-bacterial, anti-tumor, and anti-plasmodial activities. The quinaldic acid (QA) moiety-containing side ring (loop 2) was proven to play an important role in carrying out these functions. Previously, we proposed biosynthetic logic for thiostrepton loop 2 and demonstrated the formation mechanism of QA. Herein, we report the discovery and efficient synthesis of a biologically active alkaloid, that is, a key intermediate involved in the thiostrepton biosynthetic pathway. A chemoenzymatic method was performed to synthesize the molecule, and a series of analogs were prepared for bioassays, which included the examination of anti-bacterial and anti-tumor activities. (C) 2014 Elsevier Ltd. All rights reserved.
语种: 英语
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内容类型: 期刊论文
URI标识: http://ir.sioc.ac.cn/handle/331003/38955
Appears in Collections:生命有机化学国家重点实验室_期刊论文

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作者单位: 1.中科院上海有机化学研究所
2.湖州生物制造创新中心

Recommended Citation:
Zheng QF,Wang SF,Liu W. Discovery and efficient synthesis of a biologically active alkaloid inspired by thiostrepton biosynthesis[J]. Tetrahedron,2014,70(42):7686-7690.
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