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Discovery and efficient synthesis of a biologically active alkaloid inspired by thiostrepton biosynthesis
其他题名受硫链丝菌素生物合成的启发发现和高效合成具有生物活性的生物碱
Zheng QF(郑庆飞)1; Wang SF(王守锋)1; Liu W(刘文)1
2014
发表期刊Tetrahedron
卷号70期号:42页码:7686-7690
摘要Thiostrepton, a natural peptide macrocycle, is of great interest due to its structural complexity and numerous biological activities, including anti-bacterial, anti-tumor, and anti-plasmodial activities. The quinaldic acid (QA) moiety-containing side ring (loop 2) was proven to play an important role in carrying out these functions. Previously, we proposed biosynthetic logic for thiostrepton loop 2 and demonstrated the formation mechanism of QA. Herein, we report the discovery and efficient synthesis of a biologically active alkaloid, that is, a key intermediate involved in the thiostrepton biosynthetic pathway. A chemoenzymatic method was performed to synthesize the molecule, and a series of analogs were prepared for bioassays, which included the examination of anti-bacterial and anti-tumor activities. (C) 2014 Elsevier Ltd. All rights reserved.
学科领域生命有机化学
DOI10.1016/j.tet.2014.06.076
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收录类别SCI
语种英语
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文献类型期刊论文
条目标识符http://ir.sioc.ac.cn/handle/331003/38955
专题生命有机化学国家重点实验室
通讯作者Liu W(刘文)
作者单位1.中科院上海有机化学研究所
2.湖州生物制造创新中心
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GB/T 7714
Zheng QF,Wang SF,Liu W. Discovery and efficient synthesis of a biologically active alkaloid inspired by thiostrepton biosynthesis[J]. Tetrahedron,2014,70(42):7686-7690.
APA 郑庆飞,王守锋,&刘文.(2014).Discovery and efficient synthesis of a biologically active alkaloid inspired by thiostrepton biosynthesis.Tetrahedron,70(42),7686-7690.
MLA 郑庆飞,et al."Discovery and efficient synthesis of a biologically active alkaloid inspired by thiostrepton biosynthesis".Tetrahedron 70.42(2014):7686-7690.
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