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Discovery and efficient synthesis of a biologically active alkaloid inspired by thiostrepton biosynthesis
Alternative Title受硫链丝菌素生物合成的启发发现和高效合成具有生物活性的生物碱
Zheng QF(郑庆飞)1; Wang SF(王守锋)1; Liu W(刘文)1
2014
Source PublicationTetrahedron
Volume70Issue:42Pages:7686-7690
AbstractThiostrepton, a natural peptide macrocycle, is of great interest due to its structural complexity and numerous biological activities, including anti-bacterial, anti-tumor, and anti-plasmodial activities. The quinaldic acid (QA) moiety-containing side ring (loop 2) was proven to play an important role in carrying out these functions. Previously, we proposed biosynthetic logic for thiostrepton loop 2 and demonstrated the formation mechanism of QA. Herein, we report the discovery and efficient synthesis of a biologically active alkaloid, that is, a key intermediate involved in the thiostrepton biosynthetic pathway. A chemoenzymatic method was performed to synthesize the molecule, and a series of analogs were prepared for bioassays, which included the examination of anti-bacterial and anti-tumor activities. (C) 2014 Elsevier Ltd. All rights reserved.
Subject Area生命有机化学
DOI10.1016/j.tet.2014.06.076
URL查看原文
Indexed BySCI
Language英语
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Document Type期刊论文
Identifierhttp://ir.sioc.ac.cn/handle/331003/38955
Collection生命有机化学国家重点实验室
Corresponding AuthorLiu W(刘文)
Affiliation1.中科院上海有机化学研究所
2.湖州生物制造创新中心
Recommended Citation
GB/T 7714
Zheng QF,Wang SF,Liu W. Discovery and efficient synthesis of a biologically active alkaloid inspired by thiostrepton biosynthesis[J]. Tetrahedron,2014,70(42):7686-7690.
APA 郑庆飞,王守锋,&刘文.(2014).Discovery and efficient synthesis of a biologically active alkaloid inspired by thiostrepton biosynthesis.Tetrahedron,70(42),7686-7690.
MLA 郑庆飞,et al."Discovery and efficient synthesis of a biologically active alkaloid inspired by thiostrepton biosynthesis".Tetrahedron 70.42(2014):7686-7690.
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