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Alternative TitleProduction of a Trioxacarcin Analogue by Engineering of Its Biosynthetic Pathway
漆丽华1; 张媚1; 潘海学1; 陈晓东1; 唐功利1
Source Publication有机化学
Other AbstractTrioxacarcins, derived from streptomyces, are aromatic polyketide natural products with antitumor activity. The production of trioxacarcins was improved significantly by optimizing the fermentation and purification processes. The biosynthetic pathway of trioxacarcins was changed by inactivating an acyltransferase (Trx49) gene in the trioxacarcin cluster, and an analogue compound 1 lacking the O-acetyl group of sugar on C-4 was obtained. The influence of the O-acetyl group on biological activity of trioxacarcins was investigated by in vitro cytotoxicity test. Compared with trioxacarcin A, the activity of compound 1 decreases to some extent but still persists an excellent anti-tumor activity level with IC50 value of 4.86 nmol.L-1.
Subject Area生命有机化学
Indexed BySCI
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Document Type期刊论文
Corresponding Author陈晓东; 唐功利
Recommended Citation
GB/T 7714
漆丽华,张媚,潘海学,等. 基于生物合成途径改造的一个三欣卡辛类似物的发现[J]. 有机化学,2014,34(7):1376-1381.
APA 漆丽华,张媚,潘海学,陈晓东,&唐功利.(2014).基于生物合成途径改造的一个三欣卡辛类似物的发现.有机化学,34(7),1376-1381.
MLA 漆丽华,et al."基于生物合成途径改造的一个三欣卡辛类似物的发现".有机化学 34.7(2014):1376-1381.
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