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学科主题: 生命有机化学
题名: 基于生物合成途径改造的一个三欣卡辛类似物的发现
其他题名: Production of a Trioxacarcin Analogue by Engineering of Its Biosynthetic Pathway
作者: 漆丽华1; 张媚1; 潘海学1; 陈晓东1; 唐功利1
通讯作者: 陈晓东 ; 唐功利
刊名: 有机化学
发表日期: 2014
DOI: 10.6023/cjoc201403032
卷: 34, 期:7, 页:1376-1381
收录类别: SCI
英文摘要: Trioxacarcins, derived from streptomyces, are aromatic polyketide natural products with antitumor activity. The production of trioxacarcins was improved significantly by optimizing the fermentation and purification processes. The biosynthetic pathway of trioxacarcins was changed by inactivating an acyltransferase (Trx49) gene in the trioxacarcin cluster, and an analogue compound 1 lacking the O-acetyl group of sugar on C-4 was obtained. The influence of the O-acetyl group on biological activity of trioxacarcins was investigated by in vitro cytotoxicity test. Compared with trioxacarcin A, the activity of compound 1 decreases to some extent but still persists an excellent anti-tumor activity level with IC50 value of 4.86 nmol.L-1.
语种: 中文
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内容类型: 期刊论文
URI标识: http://ir.sioc.ac.cn/handle/331003/38953
Appears in Collections:生命有机化学国家重点实验室_期刊论文

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作者单位: 1.江西中医药大学
2.中科院上海有机化学研究所

Recommended Citation:
漆丽华,张媚,潘海学,等. 基于生物合成途径改造的一个三欣卡辛类似物的发现[J]. 有机化学,2014,34(7):1376-1381.
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