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Characterization of QmnD3/QmnD4 for Double Bond Formation in Quartromicin Biosynthesis
Alternative Title四重霉素生物合成中发现了QmnD3/QmnD4催化双键形成
Wu LF(吴龙飞); He HY(贺海燕); Pan HX(潘海学); Han L(韩莉); Wang RX(王任小); Tang GL(唐功利)
2014
Source PublicationOrg. Lett.
Volume16Issue:6Pages:1578-1581
AbstractIn this work, two enzymes responsible for the biogenesis of possible [4 + 2] reaction precursors in the quartromicin biosynthetic pathway were characterized: acetylation of 1 to yield 2 was catalyzed by QmnD3, and subsequent acetic acid elimination of 2 to form double bond product 3 was catalyzed by QmnD4. Site-directed mutagenesis assay of QmnD3 and QmnD4 was investigated, and a general base-catalyzed mechanism for QmnD4 is proposed.
Subject Area生命有机化学
DOI10.1021/ol500111n
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Indexed BySCI
Language英语
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Document Type期刊论文
Identifierhttp://ir.sioc.ac.cn/handle/331003/38940
Collection生命有机化学国家重点实验室
Corresponding AuthorTang GL(唐功利)
Affiliation中科院上海有机化学研究所
Recommended Citation
GB/T 7714
Wu LF,He HY,Pan HX,et al. Characterization of QmnD3/QmnD4 for Double Bond Formation in Quartromicin Biosynthesis[J]. Org. Lett.,2014,16(6):1578-1581.
APA 吴龙飞,贺海燕,潘海学,韩莉,王任小,&唐功利.(2014).Characterization of QmnD3/QmnD4 for Double Bond Formation in Quartromicin Biosynthesis.Org. Lett.,16(6),1578-1581.
MLA 吴龙飞,et al."Characterization of QmnD3/QmnD4 for Double Bond Formation in Quartromicin Biosynthesis".Org. Lett. 16.6(2014):1578-1581.
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