中国科学院上海有机化学研究所机构知识库
Advanced  
SIOC OpenIR  > 生命有机化学国家重点实验室  > 期刊论文
学科主题: 生命有机化学
题名: Characterization of QmnD3/QmnD4 for Double Bond Formation in Quartromicin Biosynthesis
其他题名: 四重霉素生物合成中发现了QmnD3/QmnD4催化双键形成
作者: Wu LF(吴龙飞); He HY(贺海燕); Pan HX(潘海学); Han L(韩莉); Wang RX(王任小); Tang GL(唐功利)
通讯作者: 唐功利
刊名: Org. Lett.
发表日期: 2014
DOI: 10.1021/ol500111n
卷: 16, 期:6, 页:1578-1581
收录类别: SCI
英文摘要: In this work, two enzymes responsible for the biogenesis of possible [4 + 2] reaction precursors in the quartromicin biosynthetic pathway were characterized: acetylation of 1 to yield 2 was catalyzed by QmnD3, and subsequent acetic acid elimination of 2 to form double bond product 3 was catalyzed by QmnD4. Site-directed mutagenesis assay of QmnD3 and QmnD4 was investigated, and a general base-catalyzed mechanism for QmnD4 is proposed.
语种: 英语
相关网址: 查看原文
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.sioc.ac.cn/handle/331003/38940
Appears in Collections:生命有机化学国家重点实验室_期刊论文

Files in This Item: Download All
File Name/ File Size Content Type Version Access License
2014150.pdf(731KB)期刊论文作者接受稿开放获取View Download

作者单位: 中科院上海有机化学研究所

Recommended Citation:
Wu LF,He HY,Pan HX,et al. Characterization of QmnD3/QmnD4 for Double Bond Formation in Quartromicin Biosynthesis[J]. Org. Lett.,2014,16(6):1578-1581.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[吴龙飞]'s Articles
[贺海燕]'s Articles
[潘海学]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[吴龙飞]‘s Articles
[贺海燕]‘s Articles
[潘海学]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit
文件名: 2014150.pdf
格式: Adobe PDF
此文件暂不支持浏览
所有评论 (0)
暂无评论
 
评注功能仅针对注册用户开放,请您登录
您对该条目有什么异议,请填写以下表单,管理员会尽快联系您。
内 容:
Email:  *
单位:
验证码:   刷新
您在IR的使用过程中有什么好的想法或者建议可以反馈给我们。
标 题:
 *
内 容:
Email:  *
验证码:   刷新

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Powered by CSpace