SIOC OpenIR  > 生命有机化学国家重点实验室
Effect of Stereochemistry of Avermectin-Like 6,6Spiroketals on Biological Activities and Endogenous Biotransformations in Streptomyces avermectinius
Alternative Title阿维菌素机构类似物中6,6-螺环的立体化学对生物活性及在除虫链霉菌中内源性生物转化的影响
Sun P(孙鹏)1; Zhao QF(赵群飞)1; Zhang H(张华)1; Wu JQ(吴杰群)1; Liu W(刘文)1
2014
Source PublicationChemBioChem
Volume15Issue:5Pages:660-664
AbstractNatural avermectins (AVEs) share a 6,6-spiroketal moiety with an exclusive R configuration at the C21 spirocyclic junction. Herein, we report the characterization of nine AVE-like spiroketals of two types (C21 S and R) in a mutant strain that lacks spirocyclase activity. Comparative analysis of their structures facilitated evaluation of the effect of stereochemistry on endogenous biotransformations and biological activities of the spiroketals.
Subject Area生命有机化学
DOI10.1002/cbic.201300616
URL查看原文
Indexed BySCI
Language英语
Citation statistics
Cited Times:8[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.sioc.ac.cn/handle/331003/38937
Collection生命有机化学国家重点实验室
Corresponding AuthorLiu W(刘文)
Affiliation1.第二军医大学
2.中科院上海有机化学研究所
3.湖州生物制造创新中心
Recommended Citation
GB/T 7714
Sun P,Zhao QF,Zhang H,et al. Effect of Stereochemistry of Avermectin-Like 6,6Spiroketals on Biological Activities and Endogenous Biotransformations in Streptomyces avermectinius[J]. ChemBioChem,2014,15(5):660-664.
APA 孙鹏,赵群飞,张华,吴杰群,&刘文.(2014).Effect of Stereochemistry of Avermectin-Like 6,6Spiroketals on Biological Activities and Endogenous Biotransformations in Streptomyces avermectinius.ChemBioChem,15(5),660-664.
MLA 孙鹏,et al."Effect of Stereochemistry of Avermectin-Like 6,6Spiroketals on Biological Activities and Endogenous Biotransformations in Streptomyces avermectinius".ChemBioChem 15.5(2014):660-664.
Files in This Item:
File Name/Size DocType Version Access License
2014121.pdf(285KB)期刊论文作者接受稿开放获取CC BY-NC-SAApplication Full Text
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[孙鹏]'s Articles
[赵群飞]'s Articles
[张华]'s Articles
Baidu academic
Similar articles in Baidu academic
[孙鹏]'s Articles
[赵群飞]'s Articles
[张华]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[孙鹏]'s Articles
[赵群飞]'s Articles
[张华]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.