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学科主题: 生命有机化学
题名: Effect of Stereochemistry of Avermectin-Like 6,6Spiroketals on Biological Activities and Endogenous Biotransformations in Streptomyces avermectinius
其他题名: 阿维菌素机构类似物中6,6-螺环的立体化学对生物活性及在除虫链霉菌中内源性生物转化的影响
作者: Sun P(孙鹏)1; Zhao QF(赵群飞)1; Zhang H(张华)1; Wu JQ(吴杰群)1; Liu W(刘文)1
通讯作者: 刘文
刊名: ChemBioChem
发表日期: 2014
DOI: 10.1002/cbic.201300616
卷: 15, 期:5, 页:660-664
收录类别: SCI
英文摘要: Natural avermectins (AVEs) share a 6,6-spiroketal moiety with an exclusive R configuration at the C21 spirocyclic junction. Herein, we report the characterization of nine AVE-like spiroketals of two types (C21 S and R) in a mutant strain that lacks spirocyclase activity. Comparative analysis of their structures facilitated evaluation of the effect of stereochemistry on endogenous biotransformations and biological activities of the spiroketals.
语种: 英语
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内容类型: 期刊论文
URI标识: http://ir.sioc.ac.cn/handle/331003/38937
Appears in Collections:生命有机化学国家重点实验室_期刊论文

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作者单位: 1.第二军医大学
2.中科院上海有机化学研究所
3.湖州生物制造创新中心

Recommended Citation:
Sun P,Zhao QF,Zhang H,et al. Effect of Stereochemistry of Avermectin-Like 6,6Spiroketals on Biological Activities and Endogenous Biotransformations in Streptomyces avermectinius[J]. ChemBioChem,2014,15(5):660-664.
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