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学科主题: 生命有机化学
题名: Characterization of AvaR1, an autoregulator receptor that negatively controls avermectins production in a high avermectin-producing strain
其他题名: 阿维菌素高产菌中AvaR作为一个自调控受体负调控阿维菌素产生
作者: Wang JB(王健博); Zhang F(张凤); Pu JY(蒲津越); Zhao J(赵娟); Zhao QF(赵群飞); Tang GL(唐功利)
通讯作者: 唐功利
刊名: Biotechnol. Lett.
发表日期: 2014
DOI: 10.1007/s10529-013-1416-y
卷: 36, 期:4, 页:813-819
收录类别: SCI
英文摘要: Many gamma-butyrolactone-autoregulator receptors control the production of secondary metabolites in Streptomyces spp. Hence, AvaR1, an autoregulator receptor protein in Streptomyces avermitilis, was characterized as a negative regulator of avermectin (Ave) production. Deletion of AvaR1 in a high-producing strain increased production of Ave B1a approx. 1.75 times (similar to 700 mu g/ml) compared with the parent strain. Semi-quantitative RT-PCR and electrophoretic mobility shift assays revealed that AvaR1 regulates the biosynthesis of Ave but not through the aveR pathway-specific regulatory gene. A special signaling molecule, avenolide, increased production of Ave. This study has refined our understanding of how avenolide regulates the production of Aves which is promising for developing new methods to improve the production of antibiotics in industrial strains.
语种: 英语
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内容类型: 期刊论文
URI标识: http://ir.sioc.ac.cn/handle/331003/38936
Appears in Collections:生命有机化学国家重点实验室_期刊论文

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作者单位: 中科院上海有机化学研究所

Recommended Citation:
Wang JB,Zhang F,Pu JY,et al. Characterization of AvaR1, an autoregulator receptor that negatively controls avermectins production in a high avermectin-producing strain[J]. Biotechnol. Lett.,2014,36(4):813-819.
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