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Covalent Functionalization of Graphene Oxide with Biocompatible Poly(ethylene glycol) for Delivery of Paclitaxel
其他题名Covalent Functionalization of Graphene Oxide with Biocompatible Poly(ethylene glycol) for Delivery of Paclitaxel
Xu ZY(徐志远)1; Wang S(王松)1; Li YJ(李永军)1; Wang MW(王明伟)1; Shi P(史萍)1; Huang XY(黄晓宇)1
2014
发表期刊ACS Appl. Mater. Interfaces
卷号6期号:19页码:17268-17276
摘要Graphene oxide (GO), a novel 2D nanomaterial prepared by the oxidation of natural graphite, has been paid much attention in the area of drug delivery due to good biocompatibility and low toxicity. In the present work, 6-armed poly(ethylene glycol) was covalently introduced into the surface of GO sheets via a facile amidation process under mild conditions, making the modified GO, GO-PEG (PEG: 65 wt %, size: 50-200 nm), stable and biocompatible in physiological solution. This nanosized GO-PEG was found to be nontoxic to human lung cancer A549 and human breast cancer MCF-7 cells via cell viability assay. Furthermore, paclitaxel (PTX), a widely used cancer chemotherapy drug, was conjugated onto GO-PEG via pi-pi stacking and hydrophobic interactions to afford a nanocomplex of GO-PEG/PTX with a relatively high loading capacity for PTX (11.2 wt %). This complex could quickly enter into A549 and MCF-7 cells evidenced by inverted fluorescence microscopy using Fluorescein isothiocyanate as a probe, and it also showed remarkably high cytotoxicity to A549 and MCF-7 cells in a broad range of concentration of PTX and time compared to free PTX. This kind of nanoscale drug delivery system on the basis of PEGylated GO may find potential application in biomedicine.
学科领域高分子化学
DOI10.1021/am505308f
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收录类别SCI
语种英语
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文献类型期刊论文
条目标识符http://ir.sioc.ac.cn/handle/331003/38909
专题高分子材料研究室
通讯作者Li YJ(李永军); Shi P(史萍); Huang XY(黄晓宇)
作者单位1.中科院上海有机化学研究所
2.华东理工大学
3.复旦大学
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GB/T 7714
Xu ZY,Wang S,Li YJ,et al. Covalent Functionalization of Graphene Oxide with Biocompatible Poly(ethylene glycol) for Delivery of Paclitaxel[J]. ACS Appl. Mater. Interfaces,2014,6(19):17268-17276.
APA 徐志远,王松,李永军,王明伟,史萍,&黄晓宇.(2014).Covalent Functionalization of Graphene Oxide with Biocompatible Poly(ethylene glycol) for Delivery of Paclitaxel.ACS Appl. Mater. Interfaces,6(19),17268-17276.
MLA 徐志远,et al."Covalent Functionalization of Graphene Oxide with Biocompatible Poly(ethylene glycol) for Delivery of Paclitaxel".ACS Appl. Mater. Interfaces 6.19(2014):17268-17276.
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