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Covalent Functionalization of Graphene Oxide with Biocompatible Poly(ethylene glycol) for Delivery of Paclitaxel
Alternative TitleCovalent Functionalization of Graphene Oxide with Biocompatible Poly(ethylene glycol) for Delivery of Paclitaxel
Xu ZY(徐志远)1; Wang S(王松)1; Li YJ(李永军)1; Wang MW(王明伟)1; Shi P(史萍)1; Huang XY(黄晓宇)1
2014
Source PublicationACS Appl. Mater. Interfaces
Volume6Issue:19Pages:17268-17276
AbstractGraphene oxide (GO), a novel 2D nanomaterial prepared by the oxidation of natural graphite, has been paid much attention in the area of drug delivery due to good biocompatibility and low toxicity. In the present work, 6-armed poly(ethylene glycol) was covalently introduced into the surface of GO sheets via a facile amidation process under mild conditions, making the modified GO, GO-PEG (PEG: 65 wt %, size: 50-200 nm), stable and biocompatible in physiological solution. This nanosized GO-PEG was found to be nontoxic to human lung cancer A549 and human breast cancer MCF-7 cells via cell viability assay. Furthermore, paclitaxel (PTX), a widely used cancer chemotherapy drug, was conjugated onto GO-PEG via pi-pi stacking and hydrophobic interactions to afford a nanocomplex of GO-PEG/PTX with a relatively high loading capacity for PTX (11.2 wt %). This complex could quickly enter into A549 and MCF-7 cells evidenced by inverted fluorescence microscopy using Fluorescein isothiocyanate as a probe, and it also showed remarkably high cytotoxicity to A549 and MCF-7 cells in a broad range of concentration of PTX and time compared to free PTX. This kind of nanoscale drug delivery system on the basis of PEGylated GO may find potential application in biomedicine.
Subject Area高分子化学
DOI10.1021/am505308f
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Indexed BySCI
Language英语
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Cited Times:90[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.sioc.ac.cn/handle/331003/38909
Collection高分子材料研究室
Corresponding AuthorLi YJ(李永军); Shi P(史萍); Huang XY(黄晓宇)
Affiliation1.中科院上海有机化学研究所
2.华东理工大学
3.复旦大学
Recommended Citation
GB/T 7714
Xu ZY,Wang S,Li YJ,et al. Covalent Functionalization of Graphene Oxide with Biocompatible Poly(ethylene glycol) for Delivery of Paclitaxel[J]. ACS Appl. Mater. Interfaces,2014,6(19):17268-17276.
APA 徐志远,王松,李永军,王明伟,史萍,&黄晓宇.(2014).Covalent Functionalization of Graphene Oxide with Biocompatible Poly(ethylene glycol) for Delivery of Paclitaxel.ACS Appl. Mater. Interfaces,6(19),17268-17276.
MLA 徐志远,et al."Covalent Functionalization of Graphene Oxide with Biocompatible Poly(ethylene glycol) for Delivery of Paclitaxel".ACS Appl. Mater. Interfaces 6.19(2014):17268-17276.
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