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Cholesterol-based cationic lipids for gene delivery: Contribution of molecular structure factors to physico-chemical and biological properties
其他题名基于甾体化合物的脂质体基因载体: 分子结构因子对物理化学性能和生物性能的贡献
Sheng RL(盛瑞隆); Luo T(罗挺); Li H(李慧); Sun JJ(孙景景); Wang Z(王昭); Cao AM(曹阿民)
2014
发表期刊Colloid Surf. B-Biointerfaces
卷号116页码:32-40
摘要In this work, we prepared a series of cholesterol-based cationic (Cho-cat) lipids bearing cholesterol hydrophobe, natural amino acid headgroups (lysine/histidine) and linkage (carbonate ester/ether) bonds. In which, the natural amino acid headgroups made dominant contribution to their physico-chemical and biological properties. Among the lipids, the L-lysine headgroup bearing lipids (Cho-es/et-Lys) showed higher pDNA binding affinity and were able to form larger sized and higher surface charged lipoplexes than that of L-histidine headgroup bearing lipids (Cho-es/et-His), they also demonstrated higher transfection efficacy and higher membrane disruption capacities than that of their L-histidine headgroup bearing counterparts. However, compared to the contributions of the headgroups, the (carbonate ester/ether) linkage bonds showed much less affects. Besides, it could be noted that, Cho-es/et-Lys lipids exhibited very high luciferase gene transfection efficiency that almost reached the transfection level of "gold standard" bPEI-25k, made them potential transfection reagents for practical application. Moreover, the results facilitated the understanding for the structure activity relationship of the cholesterol-based cationic lipids, and also paved a simple and efficient way for achieving high transfection efficiency by modification of suitable headgroups on lipid gene carriers. (C) 2014 Elsevier B.V. All rights reserved.
学科领域高分子化学
DOI10.1016/j.colsurfb.2013.12.039
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收录类别SCI
语种英语
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被引频次:15[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.sioc.ac.cn/handle/331003/38892
专题高分子材料研究室
通讯作者Cao AM(曹阿民)
作者单位中科院上海有机化学研究所
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GB/T 7714
Sheng RL,Luo T,Li H,et al. Cholesterol-based cationic lipids for gene delivery: Contribution of molecular structure factors to physico-chemical and biological properties[J]. Colloid Surf. B-Biointerfaces,2014,116:32-40.
APA 盛瑞隆,罗挺,李慧,孙景景,王昭,&曹阿民.(2014).Cholesterol-based cationic lipids for gene delivery: Contribution of molecular structure factors to physico-chemical and biological properties.Colloid Surf. B-Biointerfaces,116,32-40.
MLA 盛瑞隆,et al."Cholesterol-based cationic lipids for gene delivery: Contribution of molecular structure factors to physico-chemical and biological properties".Colloid Surf. B-Biointerfaces 116(2014):32-40.
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