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学科主题: 氟化学
题名: Nickel-Catalyzed Cross-Coupling of Functionalized Difluoromethyl Bromides and Chlorides with Aryl Boronic Acids: A General Method for Difluoroalkylated Arenes
其他题名: 一种通过镍催化下二氟烷基溴、氯对芳基硼酸合成二氟烷基芳烃的通用方法
作者: Xiao YL(肖玉兰); Guo WH(郭文豪); He GZ(何国珍); Pan Q(潘强); Zhang XG(张新刚)
通讯作者: 张新刚
刊名: Angew. Chem.-Int. Edit.
发表日期: 2014
DOI: 10.1002/anie.201405653
卷: 53, 期:37, 页:9909-9913
收录类别: SCI
英文摘要: Transition-metal-catalyzed difluoroalkylation of aromatics remains challenging despite the importance of difluoroalkylated arenes in medicinal chemistry. Herein, the first successful example of nickel-catalyzed difluoroalkylation of aryl boronic acids is described. The reaction allows access to a variety of functionalized difluoromethyl bromides and chlorides, and paves the way to highly cost-efficient synthesis of a wide range of difluoroalkylated arenes. The notable features of this protocol are its high generality, excellent functional-group compatibility, low-cost nickel-catalyst, and practicality for gram-scale production, thus providing a facile method for applications in drug discovery and development.
语种: 英语
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内容类型: 期刊论文
URI标识: http://ir.sioc.ac.cn/handle/331003/38883
Appears in Collections:中科院有机氟化学重点实验室_期刊论文

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作者单位: 中科院上海有机化学研究所

Recommended Citation:
Xiao YL,Guo WH,He GZ,et al. Nickel-Catalyzed Cross-Coupling of Functionalized Difluoromethyl Bromides and Chlorides with Aryl Boronic Acids: A General Method for Difluoroalkylated Arenes[J]. Angew. Chem.-Int. Edit.,2014,53(37):9909-9913.
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