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Nickel-Catalyzed Cross-Coupling of Functionalized Difluoromethyl Bromides and Chlorides with Aryl Boronic Acids: A General Method for Difluoroalkylated Arenes
Alternative Title一种通过镍催化下二氟烷基溴、氯对芳基硼酸合成二氟烷基芳烃的通用方法
Xiao YL(肖玉兰); Guo WH(郭文豪); He GZ(何国珍); Pan Q(潘强); Zhang XG(张新刚)
2014
Source PublicationAngew. Chem.-Int. Edit.
Volume53Issue:37Pages:9909-9913
AbstractTransition-metal-catalyzed difluoroalkylation of aromatics remains challenging despite the importance of difluoroalkylated arenes in medicinal chemistry. Herein, the first successful example of nickel-catalyzed difluoroalkylation of aryl boronic acids is described. The reaction allows access to a variety of functionalized difluoromethyl bromides and chlorides, and paves the way to highly cost-efficient synthesis of a wide range of difluoroalkylated arenes. The notable features of this protocol are its high generality, excellent functional-group compatibility, low-cost nickel-catalyst, and practicality for gram-scale production, thus providing a facile method for applications in drug discovery and development.
Subject Area氟化学
DOI10.1002/anie.201405653
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Indexed BySCI
Language英语
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Cited Times:127[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.sioc.ac.cn/handle/331003/38883
Collection中科院有机氟化学重点实验室
Corresponding AuthorZhang XG(张新刚)
Affiliation中科院上海有机化学研究所
Recommended Citation
GB/T 7714
Xiao YL,Guo WH,He GZ,et al. Nickel-Catalyzed Cross-Coupling of Functionalized Difluoromethyl Bromides and Chlorides with Aryl Boronic Acids: A General Method for Difluoroalkylated Arenes[J]. Angew. Chem.-Int. Edit.,2014,53(37):9909-9913.
APA 肖玉兰,郭文豪,何国珍,潘强,&张新刚.(2014).Nickel-Catalyzed Cross-Coupling of Functionalized Difluoromethyl Bromides and Chlorides with Aryl Boronic Acids: A General Method for Difluoroalkylated Arenes.Angew. Chem.-Int. Edit.,53(37),9909-9913.
MLA 肖玉兰,et al."Nickel-Catalyzed Cross-Coupling of Functionalized Difluoromethyl Bromides and Chlorides with Aryl Boronic Acids: A General Method for Difluoroalkylated Arenes".Angew. Chem.-Int. Edit. 53.37(2014):9909-9913.
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