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Synthesis of alpha,alpha-Difluoromethylene Alkynes by Palladium-Catalyzed gem-Difluoropropargylation of Aryl and Alkenyl Boron Reagents
Alternative Title通过钯催化下对芳基和烯基硼试剂的偕二氟炔丙基化合成偕二氟亚甲基炔化合物
Yu YB(喻艳波); He GZ(何国珍); Zhang XG(张新刚)
2014
Source PublicationAngew. Chem.-Int. Edit.
Volume53Issue:39Pages:10457-10461
Abstractgem-Difluoropropargyl bromides are versatile intermediates in organic synthesis, but have rarely been employed in transition-metal-catalyzed cross-coupling reactions. The first palladium-catalyzed gem-difluoropropargylation of organoboron reagents with gem-difluoropropargyl bromides is now reported. The reaction proceeds under mild reaction conditions with high regioselectivity; it features a broad substrate scope and excellent functional-group compatibility and thus provides an attractive approach for the synthesis of complex fluorinated molecules, in particular for drug discovery and development.
Subject Area氟化学
DOI10.1002/anie.201405204
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Indexed BySCI
Language英语
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Cited Times:41[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.sioc.ac.cn/handle/331003/38882
Collection中科院有机氟化学重点实验室
Corresponding AuthorZhang XG(张新刚)
Affiliation中科院上海有机化学研究所
Recommended Citation
GB/T 7714
Yu YB,He GZ,Zhang XG. Synthesis of alpha,alpha-Difluoromethylene Alkynes by Palladium-Catalyzed gem-Difluoropropargylation of Aryl and Alkenyl Boron Reagents[J]. Angew. Chem.-Int. Edit.,2014,53(39):10457-10461.
APA 喻艳波,何国珍,&张新刚.(2014).Synthesis of alpha,alpha-Difluoromethylene Alkynes by Palladium-Catalyzed gem-Difluoropropargylation of Aryl and Alkenyl Boron Reagents.Angew. Chem.-Int. Edit.,53(39),10457-10461.
MLA 喻艳波,et al."Synthesis of alpha,alpha-Difluoromethylene Alkynes by Palladium-Catalyzed gem-Difluoropropargylation of Aryl and Alkenyl Boron Reagents".Angew. Chem.-Int. Edit. 53.39(2014):10457-10461.
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