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Palladium-Catalyzed Difluoroalkylation of Aryl Boronic Acids: A New Method for the Synthesis of Aryldifluoromethylated Phosphonates and Carboxylic Acid Derivatives
其他题名Pd-催化芳基硼酸的二氟烷基化: 一种合成芳基二氟膦酸酯和芳基二氟羧酸衍生物的新方法
Feng Z(冯璋); Min QQ(闵巧桥); Xiao YL(肖玉兰); Zhang B(章博); Zhang XG(张新刚)
2014
发表期刊Angew. Chem.-Int. Edit.
卷号53期号:6页码:1669-1673
摘要The palladium-catalyzed difluoroalkylation of aryl boronic acids with bromodifluoromethylphosphonate, bromodifluoroacetate, and further derivatives has been developed. This method provides a facile and useful access to a series of functionalized difluoromethylated arenes (ArCF2PO(OEt)(2), ArCF2CO2Et, and (ArCF2CONRR2)-R-1) that have important applications in drug discovery and development. Preliminary mechanistic studies reveal that a single electron transfer (SET) pathway may be involved in the catalytic cycle.
学科领域氟化学
DOI10.1002/anie.201309535
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收录类别SCI
语种英语
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文献类型期刊论文
条目标识符http://ir.sioc.ac.cn/handle/331003/38873
专题中科院有机氟化学重点实验室
通讯作者Zhang XG(张新刚)
作者单位中科院上海有机化学研究所
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GB/T 7714
Feng Z,Min QQ,Xiao YL,et al. Palladium-Catalyzed Difluoroalkylation of Aryl Boronic Acids: A New Method for the Synthesis of Aryldifluoromethylated Phosphonates and Carboxylic Acid Derivatives[J]. Angew. Chem.-Int. Edit.,2014,53(6):1669-1673.
APA 冯璋,闵巧桥,肖玉兰,章博,&张新刚.(2014).Palladium-Catalyzed Difluoroalkylation of Aryl Boronic Acids: A New Method for the Synthesis of Aryldifluoromethylated Phosphonates and Carboxylic Acid Derivatives.Angew. Chem.-Int. Edit.,53(6),1669-1673.
MLA 冯璋,et al."Palladium-Catalyzed Difluoroalkylation of Aryl Boronic Acids: A New Method for the Synthesis of Aryldifluoromethylated Phosphonates and Carboxylic Acid Derivatives".Angew. Chem.-Int. Edit. 53.6(2014):1669-1673.
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