SIOC OpenIR  > 中科院有机氟化学重点实验室
Cooperative dual palladium/silver catalyst for direct difluoromethylation of aryl bromides and iodides
Alternative Title钯/银协同催化的芳基溴和碘化物的直接二氟甲基化研究
Gu Y(古阳); Leng XB(冷雪冰); Shen QL(沈其龙)
2014
Source PublicationNat. Commun.
Volume5Pages:5405
AbstractDifluoromethylated arenes are one of the privileged structural motifs that are important for fine tuning the biological properties of drug molecules. No general catalytic method exists for the formation of difluoromethylarenes. Previous methods for the preparation of difluoromethylarenes typically required harsh conditions, multiple steps or stoichiometric amount of catalysts. Here we report a cooperative dual palladium/silver catalyst system for direct difluoromethylation of aryl bromides and iodides under mild conditions. We develop the system by initial preparation of the putative intermediates in the dual-catalytic cycles, followed by studying the elemental steps to demonstrate the viability of the proposed cooperative catalytic cycle. The reaction is compatible with a variety of functional groups such as ester, amide, protected phenoxide, protected ketone, cyclopropyl, bromide and heteroaryl subunits such as pyrrole, benzothiazole, carbazole or pyridine.
Subject Area氟化学
DOI10.1038/ncomms6405
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Indexed BySCI
Language英语
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Cited Times:116[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.sioc.ac.cn/handle/331003/38857
Collection中科院有机氟化学重点实验室
Corresponding AuthorShen QL(沈其龙)
Affiliation中科院上海有机化学研究所
Recommended Citation
GB/T 7714
Gu Y,Leng XB,Shen QL. Cooperative dual palladium/silver catalyst for direct difluoromethylation of aryl bromides and iodides[J]. Nat. Commun.,2014,5:5405.
APA 古阳,冷雪冰,&沈其龙.(2014).Cooperative dual palladium/silver catalyst for direct difluoromethylation of aryl bromides and iodides.Nat. Commun.,5,5405.
MLA 古阳,et al."Cooperative dual palladium/silver catalyst for direct difluoromethylation of aryl bromides and iodides".Nat. Commun. 5(2014):5405.
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