SIOC OpenIR  > 中科院有机氟化学重点实验室
Cooperative dual palladium/silver catalyst for direct difluoromethylation of aryl bromides and iodides
其他题名钯/银协同催化的芳基溴和碘化物的直接二氟甲基化研究
Gu Y(古阳); Leng XB(冷雪冰); Shen QL(沈其龙)
2014
发表期刊Nat. Commun.
卷号5页码:5405
摘要Difluoromethylated arenes are one of the privileged structural motifs that are important for fine tuning the biological properties of drug molecules. No general catalytic method exists for the formation of difluoromethylarenes. Previous methods for the preparation of difluoromethylarenes typically required harsh conditions, multiple steps or stoichiometric amount of catalysts. Here we report a cooperative dual palladium/silver catalyst system for direct difluoromethylation of aryl bromides and iodides under mild conditions. We develop the system by initial preparation of the putative intermediates in the dual-catalytic cycles, followed by studying the elemental steps to demonstrate the viability of the proposed cooperative catalytic cycle. The reaction is compatible with a variety of functional groups such as ester, amide, protected phenoxide, protected ketone, cyclopropyl, bromide and heteroaryl subunits such as pyrrole, benzothiazole, carbazole or pyridine.
学科领域氟化学
DOI10.1038/ncomms6405
URL查看原文
收录类别SCI
语种英语
引用统计
被引频次:94[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.sioc.ac.cn/handle/331003/38857
专题中科院有机氟化学重点实验室
通讯作者Shen QL(沈其龙)
作者单位中科院上海有机化学研究所
推荐引用方式
GB/T 7714
Gu Y,Leng XB,Shen QL. Cooperative dual palladium/silver catalyst for direct difluoromethylation of aryl bromides and iodides[J]. Nat. Commun.,2014,5:5405.
APA 古阳,冷雪冰,&沈其龙.(2014).Cooperative dual palladium/silver catalyst for direct difluoromethylation of aryl bromides and iodides.Nat. Commun.,5,5405.
MLA 古阳,et al."Cooperative dual palladium/silver catalyst for direct difluoromethylation of aryl bromides and iodides".Nat. Commun. 5(2014):5405.
条目包含的文件
文件名称/大小 文献类型 版本类型 开放类型 使用许可
2014582.pdf(483KB)期刊论文作者接受稿开放获取CC BY-NC-SA请求全文
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[古阳]的文章
[冷雪冰]的文章
[沈其龙]的文章
百度学术
百度学术中相似的文章
[古阳]的文章
[冷雪冰]的文章
[沈其龙]的文章
必应学术
必应学术中相似的文章
[古阳]的文章
[冷雪冰]的文章
[沈其龙]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。