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学科主题: 氟化学
题名: Cooperative dual palladium/silver catalyst for direct difluoromethylation of aryl bromides and iodides
其他题名: 钯/银协同催化的芳基溴和碘化物的直接二氟甲基化研究
作者: Gu Y(古阳); Leng XB(冷雪冰); Shen QL(沈其龙)
通讯作者: 沈其龙
刊名: Nat. Commun.
发表日期: 2014
DOI: 10.1038/ncomms6405
卷: 5, 页:5405
收录类别: SCI
英文摘要: Difluoromethylated arenes are one of the privileged structural motifs that are important for fine tuning the biological properties of drug molecules. No general catalytic method exists for the formation of difluoromethylarenes. Previous methods for the preparation of difluoromethylarenes typically required harsh conditions, multiple steps or stoichiometric amount of catalysts. Here we report a cooperative dual palladium/silver catalyst system for direct difluoromethylation of aryl bromides and iodides under mild conditions. We develop the system by initial preparation of the putative intermediates in the dual-catalytic cycles, followed by studying the elemental steps to demonstrate the viability of the proposed cooperative catalytic cycle. The reaction is compatible with a variety of functional groups such as ester, amide, protected phenoxide, protected ketone, cyclopropyl, bromide and heteroaryl subunits such as pyrrole, benzothiazole, carbazole or pyridine.
语种: 英语
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内容类型: 期刊论文
URI标识: http://ir.sioc.ac.cn/handle/331003/38857
Appears in Collections:中科院有机氟化学重点实验室_期刊论文

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作者单位: 中科院上海有机化学研究所

Recommended Citation:
Gu Y,Leng XB,Shen QL. Cooperative dual palladium/silver catalyst for direct difluoromethylation of aryl bromides and iodides[J]. Nat. Commun.,2014,5:5405.
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