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Trifluoromethylated nucleic acid analogues capable of self-assembly through hydrophobic interactions
其他题名通过疏水相互作用具备自组装的能力的三氟甲基化核酸类似物
Wang RW(王若文)1; WANG CHUNMING1; CAO YANG1; ZHU ZHI1; YANG CHAOYONG1; CHEN JIANZHONG1; Qing FL(卿凤翎)1; Tan YH(谭蔚泓)1
2014
发表期刊Chem. Sci.
卷号5期号:10页码:4076-4081
摘要An artificial nucleic acid analogue capable of self-assembly into a duplex merely through hydrophobic interactions is presented. The replacement of Watson-Crick hydrogen bonding with strictly hydrophobic interactions has the potential to confer new properties and facilitate the construction of complex DNA nanodevices. To study how the hydrophobic effect works during the self-assembly of nucleic acid bases, we have designed and synthesized a series of fluorinated nucleic acids (FNA) containing 3,5-bis(trifluoromethyl)benzene (F) and nucleic acids incorporating 3,5-dimethylbenzene (M) as hydrophobic base surrogates. Our experiments illustrate that two single-stranded nucleic acid oligomers could spontaneously organize into a duplex entirely by hydrophobic base pairing if the bases were size-complementary and the intermolecular forces were sufficiently strong.
学科领域氟化学
DOI10.1039/c4sc01162g
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收录类别SCI
语种英语
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文献类型期刊论文
条目标识符http://ir.sioc.ac.cn/handle/331003/38852
专题中科院有机氟化学重点实验室
通讯作者Qing FL(卿凤翎); Tan YH(谭蔚泓)
作者单位1.湖南大学
2.厦门大学
3.浙江大学
4.中科院上海有机化学研究所
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GB/T 7714
Wang RW,WANG CHUNMING,CAO YANG,et al. Trifluoromethylated nucleic acid analogues capable of self-assembly through hydrophobic interactions[J]. Chem. Sci.,2014,5(10):4076-4081.
APA 王若文.,WANG CHUNMING.,CAO YANG.,ZHU ZHI.,YANG CHAOYONG.,...&谭蔚泓.(2014).Trifluoromethylated nucleic acid analogues capable of self-assembly through hydrophobic interactions.Chem. Sci.,5(10),4076-4081.
MLA 王若文,et al."Trifluoromethylated nucleic acid analogues capable of self-assembly through hydrophobic interactions".Chem. Sci. 5.10(2014):4076-4081.
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