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学科主题: 氟化学
题名: Trifluoromethylated nucleic acid analogues capable of self-assembly through hydrophobic interactions
其他题名: 通过疏水相互作用具备自组装的能力的三氟甲基化核酸类似物
作者: Wang RW(王若文)1; WANG CHUNMING1; CAO YANG1; ZHU ZHI1; YANG CHAOYONG1; CHEN JIANZHONG1; Qing FL(卿凤翎)1; Tan YH(谭蔚泓)1
通讯作者: 卿凤翎 ; 谭蔚泓
刊名: Chem. Sci.
发表日期: 2014
DOI: 10.1039/c4sc01162g
卷: 5, 期:10, 页:4076-4081
收录类别: SCI
英文摘要: An artificial nucleic acid analogue capable of self-assembly into a duplex merely through hydrophobic interactions is presented. The replacement of Watson-Crick hydrogen bonding with strictly hydrophobic interactions has the potential to confer new properties and facilitate the construction of complex DNA nanodevices. To study how the hydrophobic effect works during the self-assembly of nucleic acid bases, we have designed and synthesized a series of fluorinated nucleic acids (FNA) containing 3,5-bis(trifluoromethyl)benzene (F) and nucleic acids incorporating 3,5-dimethylbenzene (M) as hydrophobic base surrogates. Our experiments illustrate that two single-stranded nucleic acid oligomers could spontaneously organize into a duplex entirely by hydrophobic base pairing if the bases were size-complementary and the intermolecular forces were sufficiently strong.
语种: 英语
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内容类型: 期刊论文
URI标识: http://ir.sioc.ac.cn/handle/331003/38852
Appears in Collections:中科院有机氟化学重点实验室_期刊论文

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作者单位: 1.湖南大学
2.厦门大学
3.浙江大学
4.中科院上海有机化学研究所

Recommended Citation:
Wang RW,WANG CHUNMING,CAO YANG,et al. Trifluoromethylated nucleic acid analogues capable of self-assembly through hydrophobic interactions[J]. Chem. Sci.,2014,5(10):4076-4081.
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