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学科主题: 氟化学
题名: Stereoselective Nucleophilic Fluoromethylation of Aryl Ketones: Dynamic Kinetic Resolution of Chiral alpha-Fluoro Carbanions
其他题名: 对芳基酮的立体选择性亲核一氟甲基化: 手性α-氟代碳负离子的动态动力学拆分
作者: Shen X(沈晓); Mou WJ(缪文俊); Ni CF(倪传法); Hu JB(胡金波)
通讯作者: 胡金波
刊名: Angew. Chem.-Int. Edit.
发表日期: 2014
DOI: 10.1002/anie.201308484
卷: 53, 期:3, 页:775-779
收录类别: SCI
英文摘要: Although many methods are available for the synthesis of optically enriched monofluoromethyl secondary alcohols, synthesizing optically enriched monofluoromethyl tertiary alcohols remains a challenge. An efficient and easy-to-handle nucleophilic fluoromethylation protocol was developed. The current monofluoromethylation showed much higher facial selectivity than the corresponding difluoromethylation and proceeded via a different type of transition state. Excellent stereoselective control at the fluorinated carbon chiral center was found, an effect believed to be facilitated by the dynamic kinetic resolution of the chiral alpha-fluoro carbanions.
语种: 英语
相关网址: 查看原文
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内容类型: 期刊论文
URI标识: http://ir.sioc.ac.cn/handle/331003/38816
Appears in Collections:中科院有机氟化学重点实验室_期刊论文

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作者单位: 中科院上海有机化学研究所

Recommended Citation:
Shen X,Mou WJ,Ni CF,et al. Stereoselective Nucleophilic Fluoromethylation of Aryl Ketones: Dynamic Kinetic Resolution of Chiral alpha-Fluoro Carbanions[J]. Angew. Chem.-Int. Edit.,2014,53(3):775-779.
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