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Stereoselective Nucleophilic Fluoromethylation of Aryl Ketones: Dynamic Kinetic Resolution of Chiral alpha-Fluoro Carbanions
其他题名对芳基酮的立体选择性亲核一氟甲基化: 手性α-氟代碳负离子的动态动力学拆分
Shen X(沈晓); Mou WJ(缪文俊); Ni CF(倪传法); Hu JB(胡金波)
2014
发表期刊Angew. Chem.-Int. Edit.
卷号53期号:3页码:775-779
摘要Although many methods are available for the synthesis of optically enriched monofluoromethyl secondary alcohols, synthesizing optically enriched monofluoromethyl tertiary alcohols remains a challenge. An efficient and easy-to-handle nucleophilic fluoromethylation protocol was developed. The current monofluoromethylation showed much higher facial selectivity than the corresponding difluoromethylation and proceeded via a different type of transition state. Excellent stereoselective control at the fluorinated carbon chiral center was found, an effect believed to be facilitated by the dynamic kinetic resolution of the chiral alpha-fluoro carbanions.
学科领域氟化学
DOI10.1002/anie.201308484
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收录类别SCI
语种英语
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文献类型期刊论文
条目标识符http://ir.sioc.ac.cn/handle/331003/38816
专题中科院有机氟化学重点实验室
通讯作者Hu JB(胡金波)
作者单位中科院上海有机化学研究所
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GB/T 7714
Shen X,Mou WJ,Ni CF,et al. Stereoselective Nucleophilic Fluoromethylation of Aryl Ketones: Dynamic Kinetic Resolution of Chiral alpha-Fluoro Carbanions[J]. Angew. Chem.-Int. Edit.,2014,53(3):775-779.
APA 沈晓,缪文俊,倪传法,&胡金波.(2014).Stereoselective Nucleophilic Fluoromethylation of Aryl Ketones: Dynamic Kinetic Resolution of Chiral alpha-Fluoro Carbanions.Angew. Chem.-Int. Edit.,53(3),775-779.
MLA 沈晓,et al."Stereoselective Nucleophilic Fluoromethylation of Aryl Ketones: Dynamic Kinetic Resolution of Chiral alpha-Fluoro Carbanions".Angew. Chem.-Int. Edit. 53.3(2014):775-779.
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