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学科主题: 分析化学
题名: 爆炸条件下溶菌酶反应产物的基质辅助激光解吸-飞行时间质谱分析
其他题名: Analysis of Reaction Products of Lysozyme under the Explosion Condition by Matrix-Assisted Laser Desorption Ionization Time of Flight Mass Spectrometry
作者: 刘素红1; 夏攀1; 张成功1; 张立1; 郭寅龙1
通讯作者: 张成功 ; 郭寅龙
刊名: 有机化学
发表日期: 2014
DOI: 10.6023/cjoc201404025
卷: 34, 期:10, 页:2135-2139
收录类别: SCI
英文摘要: Identification and determination of explosives and explosive residues were a subject of continuing strong interest in analytical chemistry and forensic science. In this paper, the reaction products of lysozyme under the explosion condition were analyzed by a MALDI-TOFMS (Matrix-assisted laser desorption ionization time-of-flight mass spectrometry) method. There was no difference in the tryptic:digest between the normal lysozyme and the reaction products generated by detonator, while some adduct peaks such as [MH+17](+), [MH+18](+), [MH+28](+), [MH+32], and [MH+44](+) were discovered in the explosives. This may be attributed to the reaction between the lysozyme and the active small molecule gases such as NH3, H2O, CO/N-2, O-2, CO2, which were generated during the explosion. Characteristic peaks which were produced by lysozyme and the active small molecule gases from different explosives can be used to discriminate the six explosives. For example, H2O molecules which were generated during the exploration by tri-nitrotoluene (TNT) can specifically react with VFGRCELAAAMKRHGLDNYR (m/z 2307) to produce a characteristic peak at m/z 2325 (2307+18). Also, H2O molecules which were generated by hexahydro-1,3,5-trinitroazine (RDX) can completely react with IVSDGNGMNAWVAWRNRCK (m/z 2177) to produce a characteristic peak at m/z (2177 + 18). Characteristic peak at m/z 1301 was produced by GYSLGNWVCAAK. (m/z 1269) and O-2 molecules for the identification of pentaerythritol tetranitrate (PETN). While for black powder, O-2 and H2O can both react with IVSDGNGMNAWVAWR (m/z 1676) to produce product ions peaks at m/z 1694 and 1708. However, only the O-2 molecules can react with IVSDGNGMNAWVAWR for pyrotechnic composition. As for ammon explosive, which is a mixture of inorganic explosives and organic explosives, CO2 molecules can react with a plurality of reaction sites of lysozyme to produce a series of characteristic peaks signals such as m/z 1313 (1269+44), 1720 (1676+44), 1848 (1804+44), 2722 (2678+44).
语种: 中文
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内容类型: 期刊论文
URI标识: http://ir.sioc.ac.cn/handle/331003/38598
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作者单位: 1.中科院上海有机化学研究所
2.司法部上海司法鉴定科学技术研究所

Recommended Citation:
刘素红,夏攀,张成功,等. 爆炸条件下溶菌酶反应产物的基质辅助激光解吸-飞行时间质谱分析[J]. 有机化学,2014,34(10):2135-2139.
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