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学科主题: 分析化学
题名: Solvent-Assisted Electrospray Ionization for Direct Analysis of Various Compounds (Complex) from Low/Nonpolar Solvents and Eluents
其他题名: 溶剂辅助电喷雾离子化方法的开发用于非/低极性溶剂中样本的直接检测
作者: Zhang JT(张骏婷); Wang HY(王昊阳); Zhu W(朱微); Cai TT(蔡婷婷); Guo YL(郭寅龙)
通讯作者: 王昊阳 ; 郭寅龙
刊名: Anal. Chem.
发表日期: 2014
DOI: 10.1021/ac502656a
卷: 86, 期:18, 页:8937-8942
收录类别: SCI
英文摘要: Electrospray ionization (ESI) is a powerful ionization technique with a wide range of applications. However, the analytes in low/nonpolar solvents cannot be analyzed directly in electrospray ionization-mass spectrometry (ESI-MS), because low/nonpolar solvents are incompatible with ESI, because of their low conductivity. To circumvent this problem, we introduce an electrospray-based ionization method termed solvent-assisted electrospray ionization (SAESI). With the help of electrospray solvents at the tip of the spray needle, compounds in non-electrospray ionization-friendly solvents can be ionized directly using solvent-assisted electrospray ionization-mass spectrometry (SAESI-MS). The key features that the assistant solvent can be chosen flexibly and makes little interference to samples lead to better ionization performance in detection of organic reaction intermediates and real-time analysis of polymers and chiral drugs separated by gel permeation chromatography (GPC) and normal phase liquid chromatography (NPLC). Furthermore, it can achieve online hydrogen/deuterium (H/D) exchange reaction and even mitigate the signal suppression caused by strong acid modifiers in liquid chromatography. In addition, all parts of this device are commercially available and it only requires two parameters to be optimized, which makes SAESI easy to handle.
语种: 英语
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内容类型: 期刊论文
URI标识: http://ir.sioc.ac.cn/handle/331003/38595
Appears in Collections:分析化学研究室_期刊论文

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作者单位: 中科院上海有机化学研究所

Recommended Citation:
Zhang JT,Wang HY,Zhu W,et al. Solvent-Assisted Electrospray Ionization for Direct Analysis of Various Compounds (Complex) from Low/Nonpolar Solvents and Eluents[J]. Anal. Chem.,2014,86(18):8937-8942.
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