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A highly sensitive method for enantioseparation of fenoprofen and amino acid derivatives by capillary electrophoresis with on-line sample preconcentration
其他题名A highly sensitive method for enantioseparation of fenoprofen and amino acid derivatives by capillary electrophoresis with on-line sample preconcentration
Wang ZY(王兆彦); Liu C(刘超); Kang JW(康经武)
2011
发表期刊J. Chromatogr. A
ISSN0021-9673
卷号1218期号:13页码:1775-1779
摘要A highly sensitive method for enantioseparation of trace fenoprofen and amino acid derivatives by capillary electrophoresis (CE) with vancomycin as the chiral selector was developed. Several CE techniques, such as the partial filling, large-volume sample stacking with EOF as pump plus anion-selective exhaustive injection (LVSEP-ASEI) were involved in the present method to improve the detection sensitivity. With on-column concentration, enantioseparation of racemic fenoprofen and six 9-fluorenylmethyl chloroformate (FMOC)-amino acid derivatives (at the concentration level of ng/mL) with the background electrolyte composed of 100 mmol/L Tris-H3PO4 (pH 6.0) and 2 mmol/L vancomycin was detected readily with the UV detection at 214 nm. Successfully performing LVSEP-ASEI needs a very low EOF that could be depressed by coating the capillary with poly(dimethylacrylamide) solution. The coating also played a role to minimize the adsorption of vancomycin onto the capillary wall. Effect of the injected sample volume and the electrokinetic injection time on the peak area of the enantiomers and their resolution factor were investigated and optimized. Under the optimized conditions, more than 1000-fold enhancement in detection sensitivity compared with the normal injection was achieved. (C) 2011 Elsevier B.V. All rights reserved.
学科领域分析化学
部门归属中科院上海有机化学研究所; 兰州大学
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收录类别SCI
语种英语
WOS记录号WOS:000288837400011
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文献类型期刊论文
条目标识符http://ir.sioc.ac.cn/handle/331003/28681
专题分析化学研究室
通讯作者Kang JW(康经武)
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GB/T 7714
Wang ZY,Liu C,Kang JW. A highly sensitive method for enantioseparation of fenoprofen and amino acid derivatives by capillary electrophoresis with on-line sample preconcentration[J]. J. Chromatogr. A,2011,1218(13):1775-1779.
APA 王兆彦,刘超,&康经武.(2011).A highly sensitive method for enantioseparation of fenoprofen and amino acid derivatives by capillary electrophoresis with on-line sample preconcentration.J. Chromatogr. A,1218(13),1775-1779.
MLA 王兆彦,et al."A highly sensitive method for enantioseparation of fenoprofen and amino acid derivatives by capillary electrophoresis with on-line sample preconcentration".J. Chromatogr. A 1218.13(2011):1775-1779.
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