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学科主题: 分析化学
题名: A highly sensitive method for enantioseparation of fenoprofen and amino acid derivatives by capillary electrophoresis with on-line sample preconcentration
其他题名: A highly sensitive method for enantioseparation of fenoprofen and amino acid derivatives by capillary electrophoresis with on-line sample preconcentration
作者: Wang ZY(王兆彦) ; Liu C(刘超) ; Kang JW(康经武)
通讯作者: 康经武
刊名: J. Chromatogr. A
发表日期: 2011
卷: 1218, 期:13, 页:1775-1779
收录类别: SCI
部门归属: 中科院上海有机化学研究所; 兰州大学
英文摘要: A highly sensitive method for enantioseparation of trace fenoprofen and amino acid derivatives by capillary electrophoresis (CE) with vancomycin as the chiral selector was developed. Several CE techniques, such as the partial filling, large-volume sample stacking with EOF as pump plus anion-selective exhaustive injection (LVSEP-ASEI) were involved in the present method to improve the detection sensitivity. With on-column concentration, enantioseparation of racemic fenoprofen and six 9-fluorenylmethyl chloroformate (FMOC)-amino acid derivatives (at the concentration level of ng/mL) with the background electrolyte composed of 100 mmol/L Tris-H3PO4 (pH 6.0) and 2 mmol/L vancomycin was detected readily with the UV detection at 214 nm. Successfully performing LVSEP-ASEI needs a very low EOF that could be depressed by coating the capillary with poly(dimethylacrylamide) solution. The coating also played a role to minimize the adsorption of vancomycin onto the capillary wall. Effect of the injected sample volume and the electrokinetic injection time on the peak area of the enantiomers and their resolution factor were investigated and optimized. Under the optimized conditions, more than 1000-fold enhancement in detection sensitivity compared with the normal injection was achieved. (C) 2011 Elsevier B.V. All rights reserved.
语种: 英语
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WOS记录号: WOS:000288837400011
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内容类型: 期刊论文
URI标识: http://ir.sioc.ac.cn/handle/331003/28681
Appears in Collections:分析化学研究室_期刊论文

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Recommended Citation:
Wang ZY,Liu C,Kang JW. A highly sensitive method for enantioseparation of fenoprofen and amino acid derivatives by capillary electrophoresis with on-line sample preconcentration[J]. J. Chromatogr. A,2011,1218(13):1775-1779.
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