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学科主题: 分析化学
题名: Determination of hazardous volatile organic compounds in the Hoffmann list by ion-molecule reaction mass spectrometry
其他题名: 分子离子反应质谱对霍夫曼列表中挥发性的危险有机物的测定
作者: Wang HY(王昊阳) ; Xie WY(谢雯燕) ; Chen M(陈敏) ; Liu BZ(刘百战) ; Guo YL(郭寅龙)
通讯作者: 王昊阳 ; 刘百战
刊名: Rapid Commun. Mass Spectrom.
发表日期: 2012
卷: 26, 期:16, 页:1841-1848
收录类别: SCI
部门归属: 中科院上海有机化学研究所; 上海烟草集团
英文摘要: RATIONALE Off-line gas or liquid chromatographic mass spectrometry techniques are the most widely used method for analysis of hazardous, carcinogenic volatile organic compounds (VOCs) in mainstream cigarette smoke. However, these conventional techniques can lead to modification of VOCs during sample preparation due to the high reactivity of VOCs. Thus, the development of on-line mass spectrometric methods for analysis of VOCs is desirable to circumvent this problem. METHODS The accurate identification of VOCs is a critical step in the analysis of cigarette smoke. Here, we use ion-molecule reaction mass spectrometry (IMR-MS) to study the behavior of standard VOCs in the Hoffmann list during this analytical procedure, and then to profile the VOCs in mainstream cigarette smoke using this on-line mass spectrometric method. RESULTS We first discuss and summarize the charge transfer (CT) ionization and further fragmentation of 20 standard VOCs in the Hoffmann list with the ion reagents Hg+, Xe+, and Kr+. The IMR-MS instrument was then connected to a Borgwaldt-RM20H rotary smoking machine in order to study VOCs in mainstream cigarette smoke on-line. Using this procedure, more than 20 VOCs were identified by IMR-MS by comparison with experimental results obtained on standard VOCs. CONCLUSIONS The IMR-MS technique can potentially result in reduced molecular fragmentation during analysis of VOCs. However, significant fragmentation still occurs during IMR-MS when the ionization energy (IE) of the ion reagent is much higher than the IE of the VOC, given that excess energy is stored in the newly formed ion during CT ionization. Given that IMR-MS cannot distinguish between isobaric compounds or isomers, we summarize the possible overlapping mass peaks from these isobaric species that may be present in analyses of VOCs. Selection of the ion reagent for IMR-MS should be based on the need to ensure CT ionization of the analytes, as well as avoiding their severe fragmentation. Copyright (C) 2012 John Wiley & Sons, Ltd.
语种: 英语
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WOS记录号: WOS:000306279800014
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内容类型: 期刊论文
URI标识: http://ir.sioc.ac.cn/handle/331003/28679
Appears in Collections:分析化学研究室_期刊论文

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Recommended Citation:
Wang HY,Xie WY,Chen M,et al. Determination of hazardous volatile organic compounds in the Hoffmann list by ion-molecule reaction mass spectrometry[J]. Rapid Commun. Mass Spectrom.,2012,26(16):1841-1848.
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