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Determination of hazardous volatile organic compounds in the Hoffmann list by ion-molecule reaction mass spectrometry
其他题名分子离子反应质谱对霍夫曼列表中挥发性的危险有机物的测定
Wang HY(王昊阳); Xie WY(谢雯燕); Chen M(陈敏); Liu BZ(刘百战); Guo YL(郭寅龙)
2012
发表期刊Rapid Commun. Mass Spectrom.
ISSN0951-4198
卷号26期号:16页码:1841-1848
摘要RATIONALE Off-line gas or liquid chromatographic mass spectrometry techniques are the most widely used method for analysis of hazardous, carcinogenic volatile organic compounds (VOCs) in mainstream cigarette smoke. However, these conventional techniques can lead to modification of VOCs during sample preparation due to the high reactivity of VOCs. Thus, the development of on-line mass spectrometric methods for analysis of VOCs is desirable to circumvent this problem. METHODS The accurate identification of VOCs is a critical step in the analysis of cigarette smoke. Here, we use ion-molecule reaction mass spectrometry (IMR-MS) to study the behavior of standard VOCs in the Hoffmann list during this analytical procedure, and then to profile the VOCs in mainstream cigarette smoke using this on-line mass spectrometric method. RESULTS We first discuss and summarize the charge transfer (CT) ionization and further fragmentation of 20 standard VOCs in the Hoffmann list with the ion reagents Hg+, Xe+, and Kr+. The IMR-MS instrument was then connected to a Borgwaldt-RM20H rotary smoking machine in order to study VOCs in mainstream cigarette smoke on-line. Using this procedure, more than 20 VOCs were identified by IMR-MS by comparison with experimental results obtained on standard VOCs. CONCLUSIONS The IMR-MS technique can potentially result in reduced molecular fragmentation during analysis of VOCs. However, significant fragmentation still occurs during IMR-MS when the ionization energy (IE) of the ion reagent is much higher than the IE of the VOC, given that excess energy is stored in the newly formed ion during CT ionization. Given that IMR-MS cannot distinguish between isobaric compounds or isomers, we summarize the possible overlapping mass peaks from these isobaric species that may be present in analyses of VOCs. Selection of the ion reagent for IMR-MS should be based on the need to ensure CT ionization of the analytes, as well as avoiding their severe fragmentation. Copyright (C) 2012 John Wiley & Sons, Ltd.
学科领域分析化学
部门归属中科院上海有机化学研究所; 上海烟草集团
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收录类别SCI
语种英语
WOS记录号WOS:000306279800014
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被引频次:2[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.sioc.ac.cn/handle/331003/28679
专题分析化学研究室
通讯作者Wang HY(王昊阳); Liu BZ(刘百战)
推荐引用方式
GB/T 7714
Wang HY,Xie WY,Chen M,et al. Determination of hazardous volatile organic compounds in the Hoffmann list by ion-molecule reaction mass spectrometry[J]. Rapid Commun. Mass Spectrom.,2012,26(16):1841-1848.
APA 王昊阳,谢雯燕,陈敏,刘百战,&郭寅龙.(2012).Determination of hazardous volatile organic compounds in the Hoffmann list by ion-molecule reaction mass spectrometry.Rapid Commun. Mass Spectrom.,26(16),1841-1848.
MLA 王昊阳,et al."Determination of hazardous volatile organic compounds in the Hoffmann list by ion-molecule reaction mass spectrometry".Rapid Commun. Mass Spectrom. 26.16(2012):1841-1848.
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