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学科主题: 分析化学
题名: Comparison of Hair Fatty Alcohols by N-Alkylpyridinium Isotope Quaternization and Matrix-assisted Laser Desorption/ionization Mass Spectrometry for Drug Abuse Monitoring
其他题名: 氮烷基吡啶同位素季胺化结合基质辅助激光解析离子化质谱比较吸毒者头发脂肪醇含量
作者: Wang H(汪航) ; Wang HY(王昊阳) ; Zhang L(张立) ; Zhang J(张菁) ; Zhuo XY(卓先义) ; Huang Y(黄懿) ; Guo YL(郭寅龙)
通讯作者: 郭寅龙
刊名: Chin. J. Chem.
发表日期: 2012
卷: 30, 期:10, 页:2376-2382
收录类别: SCI
部门归属: 中科院上海有机化学研究所; 司法部司法鉴定科学技术研究所
英文摘要: Based on our previous report on N-alkylpyridinium isotope quaternization (NAPIQ) for the analysis of alcoholic and alpha,beta-unsaturated ketone compounds, we have further applied NAPIQ method in the screening of hair lipids in drug abusers. Relative isotopic quantification was used for comparison of fatty alcohols between normal and drug abuse group. The NAPIQ strategy was proven to be a high-throughput method in the metabolic comparison studies of different group samples. The attached N-cationic pyridinium significantly improved the detection sensitivity for these fatty alcohols in matrix-assisted laser desorption/ionization Fourier transform ion cyclotron resonance mass spectrometric (MALDI-FTMS) analysis. The experimental results showed that the levels of fatty alcohols in the hair of heroin abuse group decreased significantly compared with the normal groups, which may be the results of the inducing of peroxidation enzyme. NAPIQ was proven to be an effective and alternative method in the research of fatty alcoholic metabolism for drug abuse monitoring.
语种: 英语
相关网址: 查看原文
WOS记录号: WOS:000310425500019
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内容类型: 期刊论文
URI标识: http://ir.sioc.ac.cn/handle/331003/28655
Appears in Collections:分析化学研究室_期刊论文

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Recommended Citation:
Wang H,Wang HY,Zhang L,et al. Comparison of Hair Fatty Alcohols by N-Alkylpyridinium Isotope Quaternization and Matrix-assisted Laser Desorption/ionization Mass Spectrometry for Drug Abuse Monitoring[J]. Chin. J. Chem.,2012,30(10):2376-2382.
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