SIOC OpenIR  > 分析化学研究室
Comparison of Hair Fatty Alcohols by N-Alkylpyridinium Isotope Quaternization and Matrix-assisted Laser Desorption/ionization Mass Spectrometry for Drug Abuse Monitoring
其他题名氮烷基吡啶同位素季胺化结合基质辅助激光解析离子化质谱比较吸毒者头发脂肪醇含量
Wang H(汪航); Wang HY(王昊阳); Zhang L(张立); Zhang J(张菁); Zhuo XY(卓先义); Huang Y(黄懿); Guo YL(郭寅龙)
2012
发表期刊Chin. J. Chem.
ISSN1001-604X
卷号30期号:10页码:2376-2382
摘要Based on our previous report on N-alkylpyridinium isotope quaternization (NAPIQ) for the analysis of alcoholic and alpha,beta-unsaturated ketone compounds, we have further applied NAPIQ method in the screening of hair lipids in drug abusers. Relative isotopic quantification was used for comparison of fatty alcohols between normal and drug abuse group. The NAPIQ strategy was proven to be a high-throughput method in the metabolic comparison studies of different group samples. The attached N-cationic pyridinium significantly improved the detection sensitivity for these fatty alcohols in matrix-assisted laser desorption/ionization Fourier transform ion cyclotron resonance mass spectrometric (MALDI-FTMS) analysis. The experimental results showed that the levels of fatty alcohols in the hair of heroin abuse group decreased significantly compared with the normal groups, which may be the results of the inducing of peroxidation enzyme. NAPIQ was proven to be an effective and alternative method in the research of fatty alcoholic metabolism for drug abuse monitoring.
学科领域分析化学
部门归属中科院上海有机化学研究所; 司法部司法鉴定科学技术研究所
URL查看原文
收录类别SCI
语种英语
WOS记录号WOS:000310425500019
引用统计
文献类型期刊论文
条目标识符http://ir.sioc.ac.cn/handle/331003/28655
专题分析化学研究室
通讯作者Guo YL(郭寅龙)
推荐引用方式
GB/T 7714
Wang H,Wang HY,Zhang L,et al. Comparison of Hair Fatty Alcohols by N-Alkylpyridinium Isotope Quaternization and Matrix-assisted Laser Desorption/ionization Mass Spectrometry for Drug Abuse Monitoring[J]. Chin. J. Chem.,2012,30(10):2376-2382.
APA 汪航.,王昊阳.,张立.,张菁.,卓先义.,...&郭寅龙.(2012).Comparison of Hair Fatty Alcohols by N-Alkylpyridinium Isotope Quaternization and Matrix-assisted Laser Desorption/ionization Mass Spectrometry for Drug Abuse Monitoring.Chin. J. Chem.,30(10),2376-2382.
MLA 汪航,et al."Comparison of Hair Fatty Alcohols by N-Alkylpyridinium Isotope Quaternization and Matrix-assisted Laser Desorption/ionization Mass Spectrometry for Drug Abuse Monitoring".Chin. J. Chem. 30.10(2012):2376-2382.
条目包含的文件
文件名称/大小 文献类型 版本类型 开放类型 使用许可
2012520.pdf(1233KB) 开放获取--请求全文
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[汪航]的文章
[王昊阳]的文章
[张立]的文章
百度学术
百度学术中相似的文章
[汪航]的文章
[王昊阳]的文章
[张立]的文章
必应学术
必应学术中相似的文章
[汪航]的文章
[王昊阳]的文章
[张立]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。