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学科主题: 分析化学
题名: STUDY OF EFFECTS OF CIGARETTE SMOKE CONDENSATES ON ACETYLCHOLINESTERASE ACTIVITY IN HUMAN LUNG EPITHELIAL CELLS BY MATRIX-ASSISTED LASER DESORPTION/IONIZATION-FOURIER TRANSFORM MASS SPECTROMETRY
其他题名: 基质辅助激光解吸/电离傅里叶变换质谱法研究香烟烟雾凝聚物对人肺上皮细胞中乙酰胆碱酯酶活性的影响
作者: SU XIAOMING ; Zhang JX(张建勋) ; Guo YL(郭寅龙) ; ZHANG QIDONG
通讯作者: 张建勋
刊名: Anal. Lett.
发表日期: 2012
卷: 45, 期:18, 页:2687-2696
收录类别: SCI
部门归属: 郑州烟草研究所; 郑州大学; 中科院上海有机化学研究所
英文摘要: Matrix-Assisted Laser Desorption/Ionization-Fourier Transform Mass Spectrometry (MALDI-FTMS) is an emerging method for kinetic measurements and inhibitor screening of acetylcholinesterase (AChE). This method is accurate, reproducible, and was successfully applied to the analysis of various biosamples. Recent studies showed the important biological functions of acetylcholinesterase in many kinds of tumors caused by smoking; however, the effect of cigarette smoke condensates (CSCs) on AChE was unclear. Herein, the effects of CSCs on AChE activity in human lung epithelial cells were studied by MALDI-FTMS. The results showed that AChE activity in human lung epithelial cells could be inhibited by CSCs, and inhibition degree on AChE activity depended on the amount of CSCs. Owing to the close relationship of AChE to lung cancer caused by smoking, such findings provide information regarding the relation between the aggressiveness of lung tumor and cigarette smoking.
语种: 英语
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WOS记录号: WOS:000311702900004
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内容类型: 期刊论文
URI标识: http://ir.sioc.ac.cn/handle/331003/28653
Appears in Collections:分析化学研究室_期刊论文

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Recommended Citation:
SU XIAOMING,Zhang JX,Guo YL,et al. STUDY OF EFFECTS OF CIGARETTE SMOKE CONDENSATES ON ACETYLCHOLINESTERASE ACTIVITY IN HUMAN LUNG EPITHELIAL CELLS BY MATRIX-ASSISTED LASER DESORPTION/IONIZATION-FOURIER TRANSFORM MASS SPECTROMETRY[J]. Anal. Lett.,2012,45(18):2687-2696.
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