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STUDY OF EFFECTS OF CIGARETTE SMOKE CONDENSATES ON ACETYLCHOLINESTERASE ACTIVITY IN HUMAN LUNG EPITHELIAL CELLS BY MATRIX-ASSISTED LASER DESORPTION/IONIZATION-FOURIER TRANSFORM MASS SPECTROMETRY
其他题名基质辅助激光解吸/电离傅里叶变换质谱法研究香烟烟雾凝聚物对人肺上皮细胞中乙酰胆碱酯酶活性的影响
SU XIAOMING; Zhang JX(张建勋); Guo YL(郭寅龙); ZHANG QIDONG
2012
发表期刊Anal. Lett.
ISSN0003-2719
卷号45期号:18页码:2687-2696
摘要Matrix-Assisted Laser Desorption/Ionization-Fourier Transform Mass Spectrometry (MALDI-FTMS) is an emerging method for kinetic measurements and inhibitor screening of acetylcholinesterase (AChE). This method is accurate, reproducible, and was successfully applied to the analysis of various biosamples. Recent studies showed the important biological functions of acetylcholinesterase in many kinds of tumors caused by smoking; however, the effect of cigarette smoke condensates (CSCs) on AChE was unclear. Herein, the effects of CSCs on AChE activity in human lung epithelial cells were studied by MALDI-FTMS. The results showed that AChE activity in human lung epithelial cells could be inhibited by CSCs, and inhibition degree on AChE activity depended on the amount of CSCs. Owing to the close relationship of AChE to lung cancer caused by smoking, such findings provide information regarding the relation between the aggressiveness of lung tumor and cigarette smoking.
学科领域分析化学
部门归属郑州烟草研究所; 郑州大学; 中科院上海有机化学研究所
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收录类别SCI
语种英语
WOS记录号WOS:000311702900004
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文献类型期刊论文
条目标识符http://ir.sioc.ac.cn/handle/331003/28653
专题分析化学研究室
通讯作者Zhang JX(张建勋)
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SU XIAOMING,Zhang JX,Guo YL,et al. STUDY OF EFFECTS OF CIGARETTE SMOKE CONDENSATES ON ACETYLCHOLINESTERASE ACTIVITY IN HUMAN LUNG EPITHELIAL CELLS BY MATRIX-ASSISTED LASER DESORPTION/IONIZATION-FOURIER TRANSFORM MASS SPECTROMETRY[J]. Anal. Lett.,2012,45(18):2687-2696.
APA SU XIAOMING,张建勋,郭寅龙,&ZHANG QIDONG.(2012).STUDY OF EFFECTS OF CIGARETTE SMOKE CONDENSATES ON ACETYLCHOLINESTERASE ACTIVITY IN HUMAN LUNG EPITHELIAL CELLS BY MATRIX-ASSISTED LASER DESORPTION/IONIZATION-FOURIER TRANSFORM MASS SPECTROMETRY.Anal. Lett.,45(18),2687-2696.
MLA SU XIAOMING,et al."STUDY OF EFFECTS OF CIGARETTE SMOKE CONDENSATES ON ACETYLCHOLINESTERASE ACTIVITY IN HUMAN LUNG EPITHELIAL CELLS BY MATRIX-ASSISTED LASER DESORPTION/IONIZATION-FOURIER TRANSFORM MASS SPECTROMETRY".Anal. Lett. 45.18(2012):2687-2696.
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