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学科主题: 天然产物有机化学
题名: Enantioselective Synthesis of (-)-Stemoamide
其他题名: 百部酰胺的对映选择性合成
作者: Mi XW(米贤伟) ; Wang Y(王燕) ; Zhu LL(朱莉莉) ; Wang RX(王任小) ; Hong R(洪然)
通讯作者: 洪然
刊名: Synthesis
发表日期: 2012
卷: 44, 期:22, 页:3432-3440
收录类别: SCI
部门归属: 中科院上海有机化学研究所
英文摘要: An enantioselective synthesis of (-)-stemoamide is presented. Noyori's ruthenium complex catalyzed asymmetric transfer hydrogenation of an alkynone delivered the (S)-C8 stereogenic center in 97.7% ee. An iron(III) chloride promoted and bioinspired N-iminium ion cyclization afforded a 3: 1 ratio of two diastereomers in favor of the cis-isomer. The diastereomeric ratio was enriched to 50: 1 by a silver-catalyzed cycloisomerization. The subsequent dynamic ruthenium-catalyzed CO-insertion reaction secured an enantioselective total synthesis of (-)-stemoamide in 18% overall yield with high optical purity.
语种: 英语
相关网址: 查看原文
WOS记录号: WOS:000312001900003
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内容类型: 期刊论文
URI标识: http://ir.sioc.ac.cn/handle/331003/28647
Appears in Collections:中科院天然产物有机化学重点实验室_期刊论文

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Recommended Citation:
Mi XW,Wang Y,Zhu LL,et al. Enantioselective Synthesis of (-)-Stemoamide[J]. Synthesis,2012,44(22):3432-3440.
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