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学科主题: 天然产物有机化学
题名: Rhodium/diene-catalyzed asymmetric arylation of N-Boc-protected alpha,beta-unsaturated delta-lactam with arylboronic acids: enantioselective synthesis of 4-aryl-2-piperidinones
其他题名: 铑双烯配体催化的芳基硼酸对N-Boc保护的a,b-不饱和戊内酰胺的不对称芳基化反应: 对映选择性地构建2-芳基-4-哌啶酮
作者: He ZT(何智涛) ; Wei YB(魏亚兵) ; Yu HJ(于宏杰) ; Sun CY(孙彩云) ; Feng CG(冯陈国) ; Tian P(田平) ; Lin GQ(林国强)
通讯作者: 田平 ; 林国强
刊名: Tetrahedron
发表日期: 2012
卷: 68, 期:45, 页:9186-9191
收录类别: SCI
部门归属: 中科院上海有机化学研究所
英文摘要: Utilizing toluene/isopropanol (20:1 to 40:1) as a solvent and KHF2 as an additive, the rhodium/dienecatalyzed asymmetric arylation (RCAA) reaction of arylboronic acids to N-Boc-protected alpha,beta-unsaturated delta-lactam proceeded smoothly to afford chiral 4-aryl-2-piperidinones with high to excellent yields (up to 94%) and enantioselectivities (up to >99% ee). Further conversion of adduct (R)-1-(tert-butyloxycarbonyl)-4-(4-chlorophenyl)-2-piperidone to (R)-Homobaclofen hydrochloride was also presented. Crown Copyright (C) 2012 Published by Elsevier Ltd. All rights reserved.
语种: 英语
相关网址: 查看原文
WOS记录号: WOS:000309787500003
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内容类型: 期刊论文
URI标识: http://ir.sioc.ac.cn/handle/331003/28639
Appears in Collections:中科院天然产物有机化学重点实验室_期刊论文

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Recommended Citation:
He ZT,Wei YB,Yu HJ,et al. Rhodium/diene-catalyzed asymmetric arylation of N-Boc-protected alpha,beta-unsaturated delta-lactam with arylboronic acids: enantioselective synthesis of 4-aryl-2-piperidinones[J]. Tetrahedron,2012,68(45):9186-9191.
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