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学科主题: 天然产物有机化学
题名: An Efficient Total Synthesis of (-)-Huperzine A
其他题名: 石杉碱甲的高效全合成
作者: Ding R(丁瑞) ; Sun BF(孙炳峰) ; Lin GQ(林国强)
通讯作者: 孙炳峰 ; 林国强
刊名: Org. Lett.
发表日期: 2012
卷: 14, 期:17, 页:4446-4449
收录类别: SCI
部门归属: 中科院上海有机化学研究所
英文摘要: The total synthesis of Lycopodium alkaloid (-)-huperzine A has been accomplished in 10 steps with 17% overall yield from commercially abundant (R)-pulegone. The synthetic route features an efficient synthesis of 4 via a Buchwald-Hartwig coupling reaction, a dianion-mediated highly stereoselective alkylation of 4, and a rare example of an intramolecular Heck reaction of an enamine-type substrate. The stereoselective beta-elimination and the accompanying Wagner-Meerwein rearrangement are of particular interest.
语种: 英语
相关网址: 查看原文
WOS记录号: WOS:000308390000038
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内容类型: 期刊论文
URI标识: http://ir.sioc.ac.cn/handle/331003/28629
Appears in Collections:中科院天然产物有机化学重点实验室_期刊论文

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Recommended Citation:
Ding R,Sun BF,Lin GQ. An Efficient Total Synthesis of (-)-Huperzine A[J]. Org. Lett.,2012,14(17):4446-4449.
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