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Quartromicin Biosynthesis: Two Alternative Polyketide Chains Produced by One Polyketide Synthase Assembly Line
其他题名四重霉素生物合成: 一套聚酮合酶装配线生成两条不同长度的聚酮链
He HY(贺海燕); Pan HX(潘海学); Wu LF(吴龙飞); Zhang BB(张蓓蓓); Chai HB(柴翰博); Liu W(刘文); Tang GL(唐功利)
2012
发表期刊Chem. Biol.
ISSN1074-5521
卷号19期号:10页码:1313-1323
摘要The antiviral compounds quartromicins represent unique members of a family of spirotetronate natural products. In this study, a biosynthetic gene cluster of quartromicins was identified by degenerate primer PCR amplification of specific genes involved in the biosynthesis of the tetronate moiety. The biochemical results confirmed that 1,3-bisphosphoglycerate was incorporated into the tetronate ring, and the intermediates of this ring were also reconstructed in vitro. The data also suggested a module skipping strategy for the production of two alternative polyketide chains by the same polyketide synthase assembly line. These findings set the stage for further investigations of the stereodivergent intermolecular cyclization mechanism, and highlight how nature has constructed this type of C2 symmetric molecule through intermolecular dimerization.
学科领域生命有机化学
部门归属中科院上海有机化学研究所
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收录类别SCI
语种英语
WOS记录号WOS:000311526600015
引用统计
被引频次:22[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.sioc.ac.cn/handle/331003/28579
专题生命有机化学国家重点实验室
通讯作者Tang GL(唐功利)
推荐引用方式
GB/T 7714
He HY,Pan HX,Wu LF,et al. Quartromicin Biosynthesis: Two Alternative Polyketide Chains Produced by One Polyketide Synthase Assembly Line[J]. Chem. Biol.,2012,19(10):1313-1323.
APA 贺海燕.,潘海学.,吴龙飞.,张蓓蓓.,柴翰博.,...&唐功利.(2012).Quartromicin Biosynthesis: Two Alternative Polyketide Chains Produced by One Polyketide Synthase Assembly Line.Chem. Biol.,19(10),1313-1323.
MLA 贺海燕,et al."Quartromicin Biosynthesis: Two Alternative Polyketide Chains Produced by One Polyketide Synthase Assembly Line".Chem. Biol. 19.10(2012):1313-1323.
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