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学科主题: 生命有机化学
题名: Quartromicin Biosynthesis: Two Alternative Polyketide Chains Produced by One Polyketide Synthase Assembly Line
其他题名: 四重霉素生物合成: 一套聚酮合酶装配线生成两条不同长度的聚酮链
作者: He HY(贺海燕) ; Pan HX(潘海学) ; Wu LF(吴龙飞) ; Zhang BB(张蓓蓓) ; Chai HB(柴翰博) ; Liu W(刘文) ; Tang GL(唐功利)
通讯作者: 唐功利
刊名: Chem. Biol.
发表日期: 2012-01-01
卷: 19, 期:10, 页:1313-1323
收录类别: SCI
部门归属: 中科院上海有机化学研究所
英文摘要: The antiviral compounds quartromicins represent unique members of a family of spirotetronate natural products. In this study, a biosynthetic gene cluster of quartromicins was identified by degenerate primer PCR amplification of specific genes involved in the biosynthesis of the tetronate moiety. The biochemical results confirmed that 1,3-bisphosphoglycerate was incorporated into the tetronate ring, and the intermediates of this ring were also reconstructed in vitro. The data also suggested a module skipping strategy for the production of two alternative polyketide chains by the same polyketide synthase assembly line. These findings set the stage for further investigations of the stereodivergent intermolecular cyclization mechanism, and highlight how nature has constructed this type of C2 symmetric molecule through intermolecular dimerization.
语种: 英语
相关网址: 查看原文
WOS记录号: WOS:000311526600015
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内容类型: 期刊论文
URI标识: http://ir.sioc.ac.cn/handle/331003/28579
Appears in Collections:生命有机化学国家重点实验室_期刊论文

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Recommended Citation:
He HY,Pan HX,Wu LF,et al. Quartromicin Biosynthesis: Two Alternative Polyketide Chains Produced by One Polyketide Synthase Assembly Line[J]. Chem. Biol.,2012,19(10):1313-1323.
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