中国科学院上海有机化学研究所机构知识库
Advanced  
SIOC OpenIR  > 生命有机化学国家重点实验室  > 期刊论文
学科主题: 生命有机化学
题名: r-氨基丁酸与其突变受体的相互作用
其他题名: Interaction Between GABA and Mutant GABAaR
作者: 温夏夏 ; 南士滨 ; 任天瑞 ; 姚建华
刊名: 高等学校化学学报
发表日期: 2012-01-01T00:00:00Z
卷: 33, 期:11, 页:2462-2469
收录类别: SCI
部门归属: 上海师范大学; 中科院上海有机化学研究所
英文摘要: The interaction between receptor and ligand may explain the mechanism of ligand effect. Homology modeling is one of important technologies in computer-aided drug design. In this paper, a rat gamma-aminobutyric acid receptor(GABAaR) model and its beta 97Tyr mutant receptor models were built by homology modeling. The calculation results show that the interactions between gamma-aminobutyric acid(GABA) and the GABAaR and its mutants are significantly different in the docking energy and hydrogen bonds. As the numbers of fluorine atom in mutant receptors increase, the binding capacities between the receptors and ligand decrease.
语种: 中文
相关网址: 查看原文
内容类型: 期刊论文
URI标识: http://ir.sioc.ac.cn/handle/331003/28577
Appears in Collections:生命有机化学国家重点实验室_期刊论文

Files in This Item: Download All
File Name/ File Size Content Type Version Access License
2012584.pdf(3213KB)----开放获取--View Download

Recommended Citation:
温夏夏,南士滨,任天瑞,等. r-氨基丁酸与其突变受体的相互作用[J]. 高等学校化学学报,2012,33(11):2462-2469.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[温夏夏]'s Articles
[南士滨]'s Articles
[任天瑞]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[温夏夏]‘s Articles
[南士滨]‘s Articles
[任天瑞]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit
文件名: 2012584.pdf
格式: Adobe PDF
此文件暂不支持浏览
所有评论 (0)
暂无评论
 
评注功能仅针对注册用户开放,请您登录
您对该条目有什么异议,请填写以下表单,管理员会尽快联系您。
内 容:
Email:  *
单位:
验证码:   刷新
您在IR的使用过程中有什么好的想法或者建议可以反馈给我们。
标 题:
 *
内 容:
Email:  *
验证码:   刷新

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Powered by CSpace