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学科主题: 生命有机化学
题名: Insights into Pyrroindomycin Biosynthesis Reveal a Uniform Paradigm for Tetramate/Tetronate Formation
其他题名: Pyrroindomycin生物合成的研究揭示了乙酰乙酸内酰胺和乙酰乙酸内酯单元具有相似的合成机制
作者: Wu QQ(吴琼琼) ; Wu ZH(吴竹华) ; Ju XD(瞿旭东) ; Liu W(刘文)
通讯作者: 瞿旭东 ; 刘文
刊名: J. Am. Chem. Soc.
发表日期: 2012
卷: 134, 期:42, 页:17342-17345
收录类别: SCI
部门归属: 中科院上海有机化学研究所
英文摘要: The natural products pyrroindomycins (PYRs), active against various drug-resistant pathogens, possess a characteristic, cyclohexene ring spiro-linked tetramate moiety. In this study, investigation into PYR biosynthesis revealed two new proteins, both of which, phylogenetically distinct from but functionally substitutable to each other in vivo, individually catalyze a Dieckmann cyclization in vitro for converting an N-acetoacetyl-L-alanyl thioester into a tetramate. Their counterparts are commonly present in the biosynthetic pathways of spiro and polyether tetronates, supporting a uniform paradigm for tetronate/tetramate formation, which features an enzymatic way to generate the C-X (X = O or N) bond first and the C-C bond next in building of the 5-membered heterocycle.
语种: 英语
相关网址: 查看原文
WOS记录号: WOS:000310103800003
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内容类型: 期刊论文
URI标识: http://ir.sioc.ac.cn/handle/331003/28571
Appears in Collections:生命有机化学国家重点实验室_期刊论文

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Recommended Citation:
Wu QQ,Wu ZH,Ju XD,et al. Insights into Pyrroindomycin Biosynthesis Reveal a Uniform Paradigm for Tetramate/Tetronate Formation[J]. J. Am. Chem. Soc.,2012,134(42):17342-17345.
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