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学科主题: 生命有机化学
题名: 抗肿瘤活性四氢异喹啉抗生素的生物合成研究进展
其他题名: Biosynthetic Progress of the Tetrahydroisoquinoline Antitumor Antibiotics
作者: 唐满成 ; 唐功利
刊名: 有机化学
发表日期: 2012-01-01
卷: 32, 期:9, 页:1568-1576
收录类别: SCI
部门归属: 中科院上海有机化学研究所
英文摘要: Due to the unique chemical structures and antitumor activity, tetrahydroisoquinoline alkaloids have long been the focus of widespread concern of chemists and biologists. In particular, with the continuous progress of new biotechnology, the biosynthetic studies of this type of antibiotics have made rapid development over the past decade. In this paper, the main achievements of these studies are reviewed, including the biosynthesis of safracin B, saframycin A, naphthyridinomycin, quinocarcin, and ecteinascidin 743, especially the biosynthetic studies of their core tetrahydroisoquinoline ring structure, such as the core structure precursor resources, the biosynthetic pathway of these precursors, and the formation mechanism of the tetrahydroisoquinoline ring.
语种: 中文
相关网址: 查看原文
内容类型: 期刊论文
URI标识: http://ir.sioc.ac.cn/handle/331003/28569
Appears in Collections:生命有机化学国家重点实验室_期刊论文

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Recommended Citation:
唐满成,唐功利. 抗肿瘤活性四氢异喹啉抗生素的生物合成研究进展[J]. 有机化学,2012,32(9):1568-1576.
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