SIOC OpenIR  > 生命有机化学国家重点实验室
ThioFinder: A Web-Based Tool for the Identification of Thiopeptide Gene Clusters in DNA Sequences
其他题名ThioFinder: 基于WEB的硫肽类抗生素发现工具
Li Jing; Ju XD(瞿旭东); He XY(贺新义); Duan L(段炼); Wu Guojun; Bi Dexi; Deng ZX(邓子新); Liu W(刘文); Ou HY(欧竑宇)
2012
发表期刊PLoS One
ISSN1932-6203
卷号7期号:9页码:e45878
摘要Thiopeptides are a growing class of sulfur-rich, highly modified heterocyclic peptides that are mainly active against Gram-positive bacteria including various drug-resistant pathogens. Recent studies also reveal that many thiopeptides inhibit the proliferation of human cancer cells, further expanding their application potentials for clinical use. Thiopeptide biosynthesis shares a common paradigm, featuring a ribosomally synthesized precursor peptide and conserved posttranslational modifications, to afford a characteristic core system, but differs in tailoring to furnish individual members. Identification of new thiopeptide gene clusters, by taking advantage of increasing information of DNA sequences from bacteria, may facilitate new thiopeptide discovery and enrichment of the unique biosynthetic elements to produce novel drug leads by applying the principle of combinatorial biosynthesis. In this study, we have developed a web-based tool ThioFinder to rapidly identify thiopeptide biosynthetic gene cluster from DNA sequence using a profile Hidden Markov Model approach. Fifty-four new putative thiopeptide biosynthetic gene clusters were found in the sequenced bacterial genomes of previously unknown producing microorganisms. ThioFinder is fully supported by an open-access database ThioBase, which contains the sufficient information of the 99 known thiopeptides regarding the chemical structure, biological activity, producing organism, and biosynthetic gene (cluster) along with the associated genome if available. The ThioFinder website offers researchers a unique resource and great flexibility for sequence analysis of thiopeptide biosynthetic gene clusters. ThioFinder is freely available at http://db-mml.sjtu.edu.cn/ThioFinder/.
学科领域生命有机化学
部门归属上海交通大学; 中科院上海有机化学研究所
URL查看原文
收录类别SCI
语种英语
WOS记录号WOS:000309554700083
引用统计
文献类型期刊论文
条目标识符http://ir.sioc.ac.cn/handle/331003/28567
专题生命有机化学国家重点实验室
通讯作者Liu W(刘文); Ou HY(欧竑宇)
推荐引用方式
GB/T 7714
Li Jing,Ju XD,He XY,et al. ThioFinder: A Web-Based Tool for the Identification of Thiopeptide Gene Clusters in DNA Sequences[J]. PLoS One,2012,7(9):e45878.
APA Li Jing.,瞿旭东.,贺新义.,段炼.,Wu Guojun.,...&欧竑宇.(2012).ThioFinder: A Web-Based Tool for the Identification of Thiopeptide Gene Clusters in DNA Sequences.PLoS One,7(9),e45878.
MLA Li Jing,et al."ThioFinder: A Web-Based Tool for the Identification of Thiopeptide Gene Clusters in DNA Sequences".PLoS One 7.9(2012):e45878.
条目包含的文件
文件名称/大小 文献类型 版本类型 开放类型 使用许可
2012492.pdf(1233KB) 开放获取--请求全文
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Li Jing]的文章
[瞿旭东]的文章
[贺新义]的文章
百度学术
百度学术中相似的文章
[Li Jing]的文章
[瞿旭东]的文章
[贺新义]的文章
必应学术
必应学术中相似的文章
[Li Jing]的文章
[瞿旭东]的文章
[贺新义]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。