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学科主题: 生命有机化学
题名: Biosynthetic Pathway for High Structural Diversity of a Common Dilactone Core in Antimycin Production
其他题名: Biosynthetic Pathway for High Structural Diversity of a Common Dilactone Core in Antimycin Production
作者: Yan Y(闫岩) ; ZHANG LIHAN ; ITO TAKUYA ; Ju XD(瞿旭东) ; ASAKAWA YOSHINORI ; AWAKAWA TAKAYOSHI ; ABE IKURO ; Liu W(刘文)
通讯作者: 瞿旭东 ; 刘文
刊名: Org. Lett.
发表日期: 2012
卷: 14, 期:16, 页:4142-4145
收录类别: SCI
部门归属: 中科院上海有机化学研究所; 日本东京大学; 日本德岛文理学院
英文摘要: We herein report comparative analysis of two versions of the biosynthetic gene clusters of antimycins, a natural product family possessing up to 44 distinct entities. The biosynthetic pathway of antimycins is amenable to the high structural variation of the substrates, supported by successes in heterologous expression of the ant cluster and in fluorine incorporation. The latter facilitated the investigation of the structure-activity relationship into the usually invariable 3-formamidosalicylic acid moiety of the molecules.
语种: 英语
相关网址: 查看原文
WOS记录号: WOS:000307526900028
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内容类型: 期刊论文
URI标识: http://ir.sioc.ac.cn/handle/331003/28559
Appears in Collections:生命有机化学国家重点实验室_期刊论文

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Recommended Citation:
Yan Y,ZHANG LIHAN,ITO TAKUYA,et al. Biosynthetic Pathway for High Structural Diversity of a Common Dilactone Core in Antimycin Production[J]. Org. Lett.,2012,14(16):4142-4145.
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