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学科主题: 生命有机化学
题名: Evaluation of novel saponins from Psammosilene tunicoides and their analogs as immunomodulators
其他题名: 对新型的金铁锁皂甙及其类似物作为免疫调节剂的评价作为免疫调节剂
作者: ZHANG JIGANG ; Cao WJ(曹文杰) ; TIAN JUNMIAN ; YUE RONGCAI ; LI LI ; GUO BAOYU ; SHAN LEI ; Yu B(俞飚) ; Zhang WD(张卫东)
通讯作者: SHAN LEI ; 俞飚 ; 张卫东
刊名: Int. Immunopharmacol.
发表日期: 2012
卷: 14, 期:1, 页:21-26
收录类别: SCI
部门归属: 第二军医大学; 中科院上海有机化学研究所; 沈阳药科大学; King Saud Univ
英文摘要: Two original oleanane-type triterpenoid saponins, tunicosaponin A (TSA) and tunicosaponin E (TSE) were isolated from the roots of Psammosilene tunicoides. Four semi-synthetic saponin derivatives, TSA1, TSA2, TSA3, and TSA4, were synthesized from TSA: two derivatives TSE1 and TSE2 were prepared from TSE. Through comparing their hemolytic activity and effects on ovalbumin (OVA)-induced IgG response with those of Quil A, TSA2 was selected as a lead candidate to evaluate acute and hepatotoxic toxicities and adjuvant potentials on the cellular and humoral immune responses of ICR mice against OVA. TSA2 had lower hemolytic activity than Quil A and TSA (P<0.001). Furthermore, TSA2 did not cause any mortality and side effects when mice were administered subcutaneously at a dose up to 1.6 mg. Moreover, no significant hepatotoxic effect was observed in TSA2 groups in doses ranging from 0.05 mg to 0.8 mg. The Con A-, LPS-, and OVA-induced splenocyte proliferation, OVA-specific antibody levels (IgG, IgG1, IgG2a and IgG2b) and IFN-gamma, TNF-alpha, IL-2, IL-4 and IL-5 in serum were significantly enhanced by TSA2 (25 mu g/mouse). The present study of structure-activity relationship indicates that the hydrophobicity of the ester/amide chains bonds to the carboxyl group of the glucuronic acid residue at position C-3 of the triterpene aglycone and the type of sugar chain at C-28 position of saponin could affect the potential of toxicity and adjuvant. Our findings demonstrate that TSA2 possesses higher adjuvant activities with less adverse effects and should be further explored as an immunomodulator for immune responses. (C) 2012 Elsevier B.V. All rights reserved.
语种: 英语
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WOS记录号: WOS:000307693200004
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内容类型: 期刊论文
URI标识: http://ir.sioc.ac.cn/handle/331003/28555
Appears in Collections:生命有机化学国家重点实验室_期刊论文

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Recommended Citation:
ZHANG JIGANG,Cao WJ,TIAN JUNMIAN,et al. Evaluation of novel saponins from Psammosilene tunicoides and their analogs as immunomodulators[J]. Int. Immunopharmacol.,2012,14(1):21-26.
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