中国科学院上海有机化学研究所机构知识库
Advanced  
SIOC OpenIR  > 生命有机化学国家重点实验室  > 期刊论文
学科主题: 生命有机化学
题名: Regio- and stereoselective C-10 beta-H functionalization of sinomenine: an access to more potent immunomodulating derivatives
其他题名: 青藤碱C10位β-H区域及立体选择性官能团化: 一个获取更强效免疫调节衍生物的途径
作者: Lou YT(楼杨通) ; Ma LY(马利燕) ; Wang M(王蒙) ; Yin DS(尹东升) ; Zhou TT(周婷婷) ; Chen AZ(陈爱中) ; Ma Z(马钊) ; Bian C(边超) ; Wang SZ(王少仲) ; Yang ZY(杨震宇) ; Sun B(孙兵) ; Yao ZJ(姚祝军)
通讯作者: 杨震宇 ; 孙兵 ; 姚祝军
刊名: Tetrahedron
发表日期: 2012
卷: 68, 期:9, 页:2172-2178
收录类别: SCI
部门归属: 中科院上海有机化学研究所; 中科院上海生命科学研究院; 南京大学
英文摘要: Regio- and stereoselective C-10 beta-H functionalization of sinomenine, an economically available natural immunomodulating alkaloid, has been studied, developed and successfully applied to the synthesis of new immunosuppressive sinomenine derivatives in a protecting-free fashion. Regioselective oxidation of sinomenine with (diacetoxylodo)benzene (DIB) in water provided a single stable benzoquinone derivative 4, and subsequent 1,6-conjugated addition of 4 with alcohols, amines, and thiols afforded a new series of C-10 beta-H functionalized sinomenine derivatives stereoselectively. Some derivatives with a newly introduced 10 beta-bezenesulfanyl substituent exhibited much higher TNF-alpha inhibitory potency than their natural parent sinomenine. This work opens a convenient access to novel sinomenine derivatives with medicinal interests. (C) 2012 Elsevier Ltd. All rights reserved.
语种: 英语
相关网址: 查看原文
WOS记录号: WOS:000301309000014
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.sioc.ac.cn/handle/331003/28539
Appears in Collections:生命有机化学国家重点实验室_期刊论文

Files in This Item: Download All
File Name/ File Size Content Type Version Access License
2012164.pdf(848KB)----开放获取--View Download

Recommended Citation:
Lou YT,Ma LY,Wang M,et al. Regio- and stereoselective C-10 beta-H functionalization of sinomenine: an access to more potent immunomodulating derivatives[J]. Tetrahedron,2012,68(9):2172-2178.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[楼杨通]'s Articles
[马利燕]'s Articles
[王蒙]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[楼杨通]‘s Articles
[马利燕]‘s Articles
[王蒙]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit
文件名: 2012164.pdf
格式: Adobe PDF
此文件暂不支持浏览
所有评论 (0)
暂无评论
 
评注功能仅针对注册用户开放,请您登录
您对该条目有什么异议,请填写以下表单,管理员会尽快联系您。
内 容:
Email:  *
单位:
验证码:   刷新
您在IR的使用过程中有什么好的想法或者建议可以反馈给我们。
标 题:
 *
内 容:
Email:  *
验证码:   刷新

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Powered by CSpace