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学科主题: 生命有机化学
题名: Caerulomycins and Collismycins Share a Common Paradigm for 2,2 '-Bipyridine Biosynthesis via an Unusual Hybrid Polyketide-Peptide Assembly Logic
其他题名: Caerulomycins和Collismycins采用相同的非典型杂合聚酮/非核糖体聚肽合成酶合成2,2'-联二吡啶核心结构
作者: Ju XD(瞿旭东) ; Pang B(庞博) ; Zhang ZC(张志聪) ; Chen M(陈明) ; Wu ZH(吴竹华) ; Zhao QF(赵群飞) ; Zhang QL(张庆林) ; Wang YY(王银燕) ; Liu Y(刘运) ; Liu W(刘文)
通讯作者: 瞿旭东 ; 刘文
刊名: J. Am. Chem. Soc.
发表日期: 2012
卷: 134, 期:22, 页:9038-9041
收录类别: SCI
部门归属: 中科院上海有机化学研究所
英文摘要: Caerulomycins (CAEs) and collismycins (COLs), which mainly differ in sulfur decoration, are two groups of structurally similar natural products containing a 2,2'-bipyridine (2,2'-BP) core, derivatives of which have been widely used in chemistry. The biosynthetic pathways of CAEs and COLs remain elusive. In this work, cloning of the CAE biosynthetic gene cluster allowed us to mine a highly conserved gene cluster encoding COL biosynthesis in a Streptomyces strain that was previously unknown as a 2,2'-BP producer. In vitro and in vivo investigations into the biosynthesis revealed that CAEs and COLs share a common paradigm featuring an atypical hybrid polyketide synthase/nonribosomal peptide synthetase system that programs the 2,2'-BP formation. This likely involves an unusual intramolecular cyclization/rearrangement sequence, and a difference in processing of the sulfhydryl group derived from the same precursor cysteine drives the biosynthetic route toward CAEs or COLs.
语种: 英语
相关网址: 查看原文
WOS记录号: WOS:000304837800005
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内容类型: 期刊论文
URI标识: http://ir.sioc.ac.cn/handle/331003/28501
Appears in Collections:生命有机化学国家重点实验室_期刊论文

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Recommended Citation:
Ju XD,Pang B,Zhang ZC,et al. Caerulomycins and Collismycins Share a Common Paradigm for 2,2 '-Bipyridine Biosynthesis via an Unusual Hybrid Polyketide-Peptide Assembly Logic[J]. J. Am. Chem. Soc.,2012,134(22):9038-9041.
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