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学科主题: 生命有机化学
题名: A simple selective protocol for continuous two-stage fluorescent sensing of both MeHg+ and anti-MeHg+ agents in living cells
其他题名: 在活细胞中连续两个阶段荧光检测甲基汞和抗甲基汞物种的一个简单选择性策略
作者: Mei DS(梅德盛) ; He BK(何宝坤) ; Chen L(陈磊) ; Yao ZJ(姚祝军)
通讯作者: 姚祝军
刊名: Tetrahedron Lett.
发表日期: 2012
卷: 53, 期:27, 页:3463-3466
收录类别: SCI
部门归属: 中科院上海有机化学研究所; 中科院上海药物研究所; 军事医学科学院放射医学研究所
英文摘要: Methylmercury (MeHg+) is one of the most toxic mercury species targeting human nervous systems, and deficiency of a convenient and precise appraisal model for anti-MeHg+ treatment greatly slows down the step of developing clinically useful anti-MeHg+ agents. A simple visualization model has been demonstrated in this work for selective sensing of both MeHg+ and anti-MeHg+ agents in two continuous stages of one experiment in living cells, using a newly developed fluorescent pyrrolcoumarin probe. The developed sensing protocol shows great potential in the future applications of screening and evaluation of anti-MeHg+ agents. (C) 2012 Elsevier Ltd. All rights reserved.
语种: 英语
相关网址: 查看原文
WOS记录号: WOS:000306152500014
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内容类型: 期刊论文
URI标识: http://ir.sioc.ac.cn/handle/331003/28493
Appears in Collections:生命有机化学国家重点实验室_期刊论文

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Recommended Citation:
Mei DS,He BK,Chen L,et al. A simple selective protocol for continuous two-stage fluorescent sensing of both MeHg+ and anti-MeHg+ agents in living cells[J]. Tetrahedron Lett.,2012,53(27):3463-3466.
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