中国科学院上海有机化学研究所机构知识库
Advanced  
SIOC OpenIR  > 生命有机化学国家重点实验室  > 期刊论文
学科主题: 生命有机化学
题名: Thiostrepton Maturation Involving a Deesterification-Amidation Way To Process the C-Terminally Methylated Peptide Backbone
其他题名: Thiostrepton Maturation Involving a Deesterification-Amidation Way To Process the C-Terminally Methylated Peptide Backbone
作者: LIAO RIJING ; Liu W(刘文)
通讯作者: 刘文
刊名: J. Am. Chem. Soc.
发表日期: 2011
卷: 133, 期:9, 页:2852-2855
收录类别: SCI
部门归属: 中科院上海有机化学研究所
英文摘要: Thiopeptides are a class of clinically interesting and highly modified peptide antibiotics. Their biosyntheses share a common paradigm for characteristic core formation but differ in tailoring to afford individual members. Herein we report an unusual deesterification-amidation process in thiostrepton maturation to furnish the terminal amide moiety. TsrB, serving as a carboxylesterase, catalyzes the hydrolysis of the methyl ester intermediate to provide the carboxylate intermediate, which can be converted to the amide product by an amidotransferase, TsrC. These findings revealed a C-terminal methylation of the precursor peptide, which is cryptic in thiostrepton biosynthesis but potentially common in the formation of its homologous series of thiopeptides that vary in the C-terminal form as methyl ester, carboxylate, or amide.
语种: 英语
相关网址: 查看原文
WOS记录号: WOS:000289455200016
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.sioc.ac.cn/handle/331003/28477
Appears in Collections:生命有机化学国家重点实验室_期刊论文

Files in This Item: Download All
File Name/ File Size Content Type Version Access License
2011275.pdf(952KB)----开放获取--View Download

Recommended Citation:
LIAO RIJING,Liu W. Thiostrepton Maturation Involving a Deesterification-Amidation Way To Process the C-Terminally Methylated Peptide Backbone[J]. J. Am. Chem. Soc.,2011,133(9):2852-2855.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[LIAO RIJING]'s Articles
[刘文]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[LIAO RIJING]‘s Articles
[刘文]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit
文件名: 2011275.pdf
格式: Adobe PDF
此文件暂不支持浏览
所有评论 (0)
暂无评论
 
评注功能仅针对注册用户开放,请您登录
您对该条目有什么异议,请填写以下表单,管理员会尽快联系您。
内 容:
Email:  *
单位:
验证码:   刷新
您在IR的使用过程中有什么好的想法或者建议可以反馈给我们。
标 题:
 *
内 容:
Email:  *
验证码:   刷新

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Powered by CSpace