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学科主题: 生命有机化学
题名: Production of doramectin by rational engineering of the avermectin biosynthetic pathway
其他题名: 合理改造阿维菌素的生物合成途径产生多拉菌素
作者: Wang JB(王健博) ; Pan HX(潘海学) ; Tang GL(唐功利)
通讯作者: 唐功利
刊名: Bioorg. Med. Chem. Lett.
发表日期: 2011
卷: 21, 期:11, 页:3320-3323
收录类别: SCI
部门归属: 中科院上海有机化学研究所
英文摘要: In an attempt to construct a strain that produces doramectin, the loading module of Ave polyketide synthase (PKS) from Streptomyces avermitilis M1 was replaced with a cyclohexanecarboxylic (CHC) unique loading module from phoslactomycin PKS. Additionally, the CHC-CoA biosynthetic gene cassette was introduced into the engineered strain, which provided the precursor for directed biosynthesis of doramectin. The doramectin production ability of the final mutant S. avermitilis TG2002 was increased about six times and the ratio of Dor to Ave was enhanced 300 times more than the original strain. (C) 2011 Elsevier Ltd. All rights reserved.
语种: 英语
相关网址: 查看原文
WOS记录号: WOS:000290708300026
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内容类型: 期刊论文
URI标识: http://ir.sioc.ac.cn/handle/331003/28475
Appears in Collections:生命有机化学国家重点实验室_期刊论文

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Recommended Citation:
Wang JB,Pan HX,Tang GL. Production of doramectin by rational engineering of the avermectin biosynthetic pathway[J]. Bioorg. Med. Chem. Lett.,2011,21(11):3320-3323.
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