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学科主题: 生命有机化学
题名: NosA Catalyzing Carboxyl-Terminal Amide Formation in Nosiheptide Maturation via an Enamine Dealkylation on the Serine-Extended Precursor Peptide
其他题名: NosA催化诺丝七肽成熟过程中丝氨酸延伸的前体肽烯胺去烷基化而形成末端酰氨的结构
作者: Yu Y(虞沂) ; Guo H(郭恒) ; Zhang Q(张琪) ; Duan L(段炼) ; Ding Y(丁莹) ; Liao RJ(廖日晶) ; Lei C(雷春) ; Shen B(沈奔) ; Liu W(刘文)
通讯作者: 刘文
刊名: J. Am. Chem. Soc.
发表日期: 2010
卷: 132, 期:46, 页:16324-16326
收录类别: SCI
部门归属: 中国科学院上海有机化学研究所; 美国威斯康辛大学
英文摘要: The carboxyl-terminal amide group has been often found in many bioactive peptide natural products, including nosiheptide belonging to the over 80 entity-containing thiopeptide family. Upon functional characterization of a novel protein NosA in nosiheptide biosynthesis, herein we report an unusual C-terminal amide forming strategy in general for maturating certain amide-terminated thiopeptides by processing their precursor peptides featuring a serine extension. NosA acts on an intermediate bearing a bis-dehydroalanine tail and catalyzes an enamide dealkylation to remove the acrylate unit originating from the extended serine residue.
语种: 英语
相关网址: 查看原文
WOS记录号: WOS:000284792000009
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内容类型: 期刊论文
URI标识: http://ir.sioc.ac.cn/handle/331003/28463
Appears in Collections:生命有机化学国家重点实验室_期刊论文

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Recommended Citation:
Yu Y,Guo H,Zhang Q,et al. NosA Catalyzing Carboxyl-Terminal Amide Formation in Nosiheptide Maturation via an Enamine Dealkylation on the Serine-Extended Precursor Peptide[J]. J. Am. Chem. Soc.,2010,132(46):16324-16326.
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