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学科主题: 生命有机化学
题名: Moving posttranslational modifications forward to biosynthesize the glycosylated thiopeptide nocathiacin I in Nocardia sp ATCC202099
其他题名: 推进翻译后修饰在Nocardia sp ATCC202099中生物合成糖基化硫肽类抗生素诺卡噻唑菌素I
作者: Ding Y(丁莹) ; Yu Y(虞沂) ; Pan HX(潘海学) ; Guo H(郭恒) ; Li YM(李也名) ; Liu W(刘文)
通讯作者: 刘文
刊名: Mol. Biosyst.
发表日期: 2010-01-01
卷: 6, 期:7, 页:1180-1185
收录类别: SCI
部门归属: 中国科学院上海有机化学研究所
英文摘要: Characterization of the biosynthetic gene cluster of glycosylated antibiotic nocathiacin I (NOC-I) here adds new insights to thiopeptide biosynthesis, showing the NOC-specific tailoring and unusual sugar formation. NOC-I biosynthesis shares the paradigm for forming a common thiopeptide core and the generality for converting to an e series member, as that of the parent compound nosiheptide (NOS). This may permit the production of NOC-I in the genetically amenable, NOS-producing strain by building NOC-specific genes for pathway engineering.
语种: 英语
相关网址: 查看原文
WOS记录号: WOS:000278861500007
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内容类型: 期刊论文
URI标识: http://ir.sioc.ac.cn/handle/331003/28457
Appears in Collections:生命有机化学国家重点实验室_期刊论文

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Recommended Citation:
Ding Y,Yu Y,Pan HX,et al. Moving posttranslational modifications forward to biosynthesize the glycosylated thiopeptide nocathiacin I in Nocardia sp ATCC202099[J]. Mol. Biosyst.,2010,6(7):1180-1185.
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